Gene description for COL4A3
Gene name collagen, type IV, alpha 3 (Goodpasture antigen)
Gene symbol COL4A3
Other names/aliases -
Species Homo sapiens
 Database cross references - COL4A3
ExoCarta ExoCarta_1285
Entrez Gene 1285
HGNC 2204
MIM 120070
UniProt Q01955  
 COL4A3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for COL4A3
Molecular Function
    metalloendopeptidase inhibitor activity GO:0008191 NAS
    extracellular matrix structural constituent GO:0005201 IEA
    protein binding GO:0005515 IPI
    integrin binding GO:0005178 TAS
    structural molecule activity GO:0005198 NAS
Biological Process
    endothelial cell apoptotic process GO:0072577 IDA
    extracellular matrix disassembly GO:0022617 TAS
    axon guidance GO:0007411 TAS
    extracellular matrix organization GO:0030198 TAS
    sensory perception of sound GO:0007605 TAS
    negative regulation of cell proliferation GO:0008285 TAS
    collagen catabolic process GO:0030574 TAS
    blood circulation GO:0008015 TAS
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    glomerular basement membrane development GO:0032836 ISS
    cell proliferation GO:0008283 IDA
    negative regulation of endopeptidase activity GO:0010951 NAS
    cell adhesion GO:0007155 IEA
    negative regulation of angiogenesis GO:0016525 IDA
    cell surface receptor signaling pathway GO:0007166 NAS
Subcellular Localization
    collagen type IV trimer GO:0005587 IDA
    basement membrane GO:0005604 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified COL4A3 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for COL4A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Invitro Homo sapiens
2 HABP2  
Invivo Homo sapiens
3 FBLN2 2199
Invivo Homo sapiens
4 SERPINE2 5270
Invivo Homo sapiens
5 MMP9 4318
Invivo Homo sapiens
6 OSM 5008
Invitro Homo sapiens
7 MFAP2  
Reconstituted Complex Homo sapiens
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