Gene description for FRAS1
Gene name Fraser extracellular matrix complex subunit 1
Gene symbol FRAS1
Other names/aliases -
Species Homo sapiens
 Database cross references - FRAS1
ExoCarta ExoCarta_80144
Entrez Gene 80144
HGNC 19185
MIM 607830
UniProt Q86XX4  
 FRAS1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FRAS1
Molecular Function
    metal ion binding GO:0046872 IEA
Biological Process
    morphogenesis of an epithelium GO:0002009 IEA
    embryonic limb morphogenesis GO:0030326 IEA
    palate development GO:0060021 IEA
    skin development GO:0043588 IEA
    cell communication GO:0007154 IEA
    metanephros morphogenesis GO:0003338 IEA
    protein transport GO:0015031 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    extracellular matrix GO:0031012 ISS
    integral component of membrane GO:0016021 IEA
    sublamina densa GO:0061618 ISS
 Experiment description of studies that identified FRAS1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FRAS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FRAS1 is involved
No pathways found





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