Gene description for LRRTM1
Gene name leucine rich repeat transmembrane neuronal 1
Gene symbol LRRTM1
Other names/aliases -
Species Homo sapiens
 Database cross references - LRRTM1
ExoCarta ExoCarta_347730
Vesiclepedia VP_347730
Entrez Gene 347730
HGNC 19408
MIM 610867
UniProt Q86UE6  
 LRRTM1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRRTM1
Biological Process
    negative regulation of receptor internalization GO:0002091 IEA
    locomotory behavior GO:0007626 IEA
    receptor internalization GO:0031623 IEA
    protein localization to synapse GO:0035418 IEA
    exploration behavior GO:0035640 IEA
    synapse organization GO:0050808 IEA
    establishment of localization in cell GO:0051649 IEA
    positive regulation of synapse assembly GO:0051965 IEA
    long-term synaptic potentiation GO:0060291 IEA
    regulation of postsynaptic density assembly GO:0099151 IEA
    regulation of presynapse assembly GO:1905606 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    endoplasmic reticulum GO:0005783 IDA
    cell surface GO:0009986 IDA
    axon GO:0030424 IDA
    growth cone GO:0030426 IDA
    extracellular matrix GO:0031012 IBA
    excitatory synapse GO:0060076 IEA
    glutamatergic synapse GO:0098978 IEA
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IMP
    postsynaptic specialization membrane GO:0099634 IDA
    postsynaptic specialization membrane GO:0099634 IMP
 Experiment description of studies that identified LRRTM1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRRTM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB12 201475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LRFN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 C1orf43 25912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CDKAL1  
Affinity Capture-MS Homo sapiens
6 PDZD8 118987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PIGA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TMEM223  
Affinity Capture-MS Homo sapiens
9 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TYW1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 STIM1 6786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 UBE4A 9354
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CNPY3 10695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PDE3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CLSTN1 22883
Affinity Capture-MS Homo sapiens
16 SUN1 23353
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MARC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 OSBP 5007
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TMEM39A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 AMIGO1  
Affinity Capture-MS Homo sapiens
21 TAZ  
Affinity Capture-MS Homo sapiens
22 FBXW7  
Synthetic Lethality Homo sapiens
23 RETSAT 54884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 NDC1 55706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 AREL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PFKFB3 5209
Affinity Capture-MS Homo sapiens
27 TSPAN6 7105
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TTC17 55761
Affinity Capture-MS Homo sapiens
29 FRAS1 80144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SMPD2 6610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ATP13A1 57130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CISD2 493856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 LRP11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PNPLA6 10908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 KIAA0319L 79932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NSUN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PCNXL3 399909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TMEM131  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 USP33  
Affinity Capture-MS Homo sapiens
40 NUS1  
Affinity Capture-MS Homo sapiens
41 ATP2A3 489
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SPTLC2 9517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CCRN4L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRTM1 is involved
PathwayEvidenceSource
Neurexins and neuroligins TAS Reactome
Neuronal System TAS Reactome
Protein-protein interactions at synapses TAS Reactome





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