Gene description for METTL16
Gene name methyltransferase like 16
Gene symbol METTL16
Other names/aliases METT10D
Species Homo sapiens
 Database cross references - METTL16
ExoCarta ExoCarta_79066
Vesiclepedia VP_79066
Entrez Gene 79066
HGNC 28484
UniProt Q86W50  
 METTL16 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for METTL16
Molecular Function
    mRNA m(6)A methyltransferase activity GO:0001734 IDA
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    U6 snRNA 3'-end binding GO:0030629 IDA
    RNA stem-loop binding GO:0035613 IDA
    U6 snRNA (adenine-(43)-N(6))-methyltransferase activity GO:0120048 IDA
Biological Process
    mRNA processing GO:0006397 IDA
    mRNA catabolic process GO:0006402 ISS
    S-adenosylmethionine biosynthetic process GO:0006556 IDA
    post-transcriptional regulation of gene expression GO:0010608 IDA
    regulation of mRNA splicing, via spliceosome GO:0048024 IDA
    mRNA destabilization GO:0061157 ISS
    rRNA base methylation GO:0070475 IBA
    snRNA (adenine-N6)-methylation GO:0120049 IDA
    negative regulation of 3'-UTR-mediated mRNA stabilization GO:1905869 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified METTL16 in sEVs
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for METTL16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LDLR 3949
Negative Genetic Homo sapiens
4 HCCS 3052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TCEA1 6917
Co-fractionation Homo sapiens
6 KRAS 3845
Negative Genetic Homo sapiens
7 MEPCE 56257
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RIT1 6016
Negative Genetic Homo sapiens
9 METTL16 79066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 YARS 8565
Co-fractionation Homo sapiens
11 HYPM  
Affinity Capture-MS Homo sapiens
12 SSB 6741
Affinity Capture-MS Homo sapiens
13 CPSF6 11052
Affinity Capture-MS Homo sapiens
14 KPNA6 23633
Affinity Capture-MS Homo sapiens
15 NTRK1 4914
Affinity Capture-MS Homo sapiens
16 KIF14 9928
Affinity Capture-MS Homo sapiens
17 GPRC5D  
Affinity Capture-MS Homo sapiens
18 PTEN 5728
Affinity Capture-MS Homo sapiens
19 FAM50A 9130
Co-fractionation Homo sapiens
20 NHP2L1 4809
Co-fractionation Homo sapiens
21 GYPA  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which METTL16 is involved
No pathways found





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