Gene description for LPIN1
Gene name lipin 1
Gene symbol LPIN1
Other names/aliases PAP1
Species Homo sapiens
 Database cross references - LPIN1
ExoCarta ExoCarta_23175
Vesiclepedia VP_23175
Entrez Gene 23175
HGNC 13345
MIM 605518
UniProt Q14693  
 LPIN1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LPIN1
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    protein binding GO:0005515 IPI
    phosphatidate phosphatase activity GO:0008195 EXP
    phosphatidate phosphatase activity GO:0008195 IBA
    phosphatidate phosphatase activity GO:0008195 IDA
Biological Process
    triglyceride mobilization GO:0006642 ISS
    phosphatidic acid biosynthetic process GO:0006654 IEA
    mitotic nuclear membrane disassembly GO:0007077 TAS
    fatty acid catabolic process GO:0009062 IBA
    fatty acid catabolic process GO:0009062 ISS
    triglyceride biosynthetic process GO:0019432 IBA
    triglyceride biosynthetic process GO:0019432 IDA
    triglyceride biosynthetic process GO:0019432 TAS
    animal organ regeneration GO:0031100 IEA
    negative regulation of myelination GO:0031642 IEA
    cellular response to insulin stimulus GO:0032869 IBA
    positive regulation of DNA replication GO:0045740 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    phosphatidylethanolamine metabolic process GO:0046337 IDA
    phosphatidic acid metabolic process GO:0046473 IDA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nuclear envelope GO:0005635 TAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 ISS
    mitochondrial outer membrane GO:0005741 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 IDA
    nuclear membrane GO:0031965 ISS
 Experiment description of studies that identified LPIN1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LPIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARRDC3 57561
Affinity Capture-MS Homo sapiens
2 GEMIN5 25929
Affinity Capture-MS Homo sapiens
3 CSNK1E 1454
Affinity Capture-Western Homo sapiens
4 YWHAG 7532
Affinity Capture-MS Homo sapiens
5 PICK1  
Affinity Capture-MS Homo sapiens
6 BTRC 8945
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 LPIN2  
Affinity Capture-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 DYRK1A 1859
Affinity Capture-MS Homo sapiens
11 PPARA  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 NTRK1 4914
Affinity Capture-MS Homo sapiens
13 KIF14 9928
Affinity Capture-MS Homo sapiens
14 CDK6 1021
Biochemical Activity Homo sapiens
15 XPO1 7514
Affinity Capture-MS Homo sapiens
16 NFATC4 4776
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 CUL1 8454
Affinity Capture-Western Homo sapiens
18 LPIN3 64900
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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