Gene description for Hspd1
Gene name	heat shock protein 1 (chaperonin)
Gene symbol	Hspd1
Other names/aliases	60kDa Hsp60
Species	Mus musculus
Database cross references - Hspd1
ExoCarta	ExoCarta_15510
Entrez Gene	15510
UniProt	P63038
Hspd1 identified in exosomes derived from the following tissue/cell type
Macrophages	12626558
Mast cells	12626558
Pancreatic cells	19351151

Gene ontology annotations for Hspd1

Molecular Function     ubiquitin protein ligase binding GO:0031625 ISO     lipopolysaccharide binding GO:0001530 ISO     nucleotide binding GO:0000166 IEA     protein complex binding GO:0032403 ISO     protease binding GO:0002020 ISO     double-stranded RNA binding GO:0003725 ISO     insulin binding GO:0043559 ISO     protein heterodimerization activity GO:0046982 ISO     chaperone binding GO:0051087 ISO     p53 binding GO:0002039 ISO     ATP binding GO:0005524 IEA     misfolded protein binding GO:0051787 ISO     poly(A) RNA binding GO:0044822 ISO Biological Process     detection of misfolded protein GO:0002236 ISO     positive regulation of interleukin-10 production GO:0032733 ISO     MyD88-dependent toll-like receptor signaling pathway GO:0002755 ISO     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISO     positive regulation of interferon-gamma production GO:0032729 ISO     protein refolding GO:0042026 ISO     protein stabilization GO:0050821 ISO     positive regulation of apoptotic process GO:0043065 ISO     positive regulation of interleukin-6 production GO:0032755 ISO     response to unfolded protein GO:0006986 ISO     positive regulation of interferon-alpha production GO:0032727 ISO     positive regulation of interleukin-12 production GO:0032735 ISO     B cell activation GO:0042113 ISO     positive regulation of inflammatory response GO:0050729 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     protein folding GO:0006457 IEA     isotype switching to IgG isotypes GO:0048291 ISO     positive regulation of macrophage activation GO:0043032 ISO     positive regulation of T cell mediated immune response to tumor cell GO:0002842 ISO     chaperone mediated protein folding requiring cofactor GO:0051085 ISO     B cell proliferation GO:0042100 ISO     T cell activation GO:0042110 ISO     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of T cell activation GO:0050870 ISO     B cell cytokine production GO:0002368 ISO Subcellular Localization     lipopolysaccharide receptor complex GO:0046696 ISO     intracellular membrane-bounded organelle GO:0043231 IDA     coated pit GO:0005905 ISO     mitochondrion GO:0005739 ISO     cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0019907 ISO     protein complex GO:0043234 ISO     mitochondrial crista GO:0030061 ISO     early endosome GO:0005769 ISO     myelin sheath GO:0043209 IDA     secretory granule GO:0030141 ISO     zymogen granule GO:0042588 ISO     cytosol GO:0005829 ISO     coated vesicle GO:0030135 ISO     mitochondrial inner membrane GO:0005743 IDA     plasma membrane GO:0005886 IDA     cytoplasm GO:0005737 ISO     membrane raft GO:0045121 ISO     rough endoplasmic reticulum GO:0005791 ISO     Golgi apparatus GO:0005794 ISO     cell surface GO:0009986 ISO     extracellular exosome GO:0070062 ISO     extracellular space GO:0005615 ISO     membrane GO:0016020 ISO