Gene description for SLC30A7
Gene name solute carrier family 30 (zinc transporter), member 7
Gene symbol SLC30A7
Other names/aliases ZNT7
ZnT-7
ZnTL2
Species Homo sapiens
 Database cross references - SLC30A7
ExoCarta ExoCarta_148867
Entrez Gene 148867
HGNC 19306
MIM 611149
UniProt Q8NEW0  
 SLC30A7 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for SLC30A7
Molecular Function
    cation transmembrane transporter activity GO:0008324 IEA
Biological Process
    sequestering of zinc ion GO:0032119 IEA
    zinc II ion transport GO:0006829 IEA
    transmembrane transport GO:0055085 TAS
    cellular protein metabolic process GO:0044267 TAS
    cation transmembrane transport GO:0098655 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    Golgi apparatus GO:0005794 IDA
    vesicle GO:0031982 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SLC30A7 in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for SLC30A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD40 958
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC30A7 is involved
PathwayEvidenceSource
Insulin processing TAS Reactome
Zinc efflux and compartmentalization by the SLC30 family TAS Reactome





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