Gene description for SRC
Gene name SRC proto-oncogene, non-receptor tyrosine kinase
Gene symbol SRC
Other names/aliases ASV
SRC1
c-SRC
p60-Src
Species Homo sapiens
 Database cross references - SRC
ExoCarta ExoCarta_6714
Vesiclepedia VP_6714
Entrez Gene 6714
HGNC 11283
MIM 190090
UniProt P12931  
 SRC identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 34887515    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Squamous carcinoma cells 20124223    
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for SRC
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 IMP
    protein tyrosine kinase activity GO:0004713 NAS
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 NAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS
    protein kinase C binding GO:0005080 IEA
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IPI
    insulin receptor binding GO:0005158 IEA
    integrin binding GO:0005178 IPI
    integrin binding GO:0005178 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    phospholipase activator activity GO:0016004 IDA
    enzyme binding GO:0019899 IPI
    heme binding GO:0020037 IDA
    protein tyrosine kinase activator activity GO:0030296 NAS
    nuclear estrogen receptor binding GO:0030331 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    SH2 domain binding GO:0042169 IPI
    phospholipase binding GO:0043274 IPI
    transmembrane transporter binding GO:0044325 IPI
    cadherin binding GO:0045296 HDA
    ephrin receptor binding GO:0046875 IPI
    ATPase binding GO:0051117 ISS
    phosphoprotein binding GO:0051219 IPI
    BMP receptor binding GO:0070700 IPI
    connexin binding GO:0071253 IEA
    scaffold protein binding GO:0097110 IPI
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    primary ovarian follicle growth GO:0001545 IEA
    positive regulation of cytokine production GO:0001819 IEA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS
    chromatin remodeling GO:0006338 IEA
    cell adhesion GO:0007155 IBA
    signal transduction GO:0007165 TAS
    signal complex assembly GO:0007172 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    integrin-mediated signaling pathway GO:0007229 IMP
    spermatogenesis GO:0007283 IEA
    learning or memory GO:0007611 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    response to mechanical stimulus GO:0009612 IEA
    response to acidic pH GO:0010447 IEA
    negative regulation of gene expression GO:0010629 IEA
    regulation of epithelial cell migration GO:0010632 IMP
    positive regulation of epithelial cell migration GO:0010634 IMP
    positive regulation of glucose metabolic process GO:0010907 IEA
    positive regulation of protein processing GO:0010954 IEA
    skeletal muscle cell proliferation GO:0014856 IEA
    positive regulation of smooth muscle cell migration GO:0014911 IEA
    macroautophagy GO:0016236 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IMP
    regulation of cell-cell adhesion GO:0022407 IMP
    cell differentiation GO:0030154 IBA
    platelet activation GO:0030168 TAS
    forebrain development GO:0030900 IEA
    T cell costimulation GO:0031295 TAS
    negative regulation of protein-containing complex assembly GO:0031333 IMP
    protein destabilization GO:0031648 IEA
    response to nutrient levels GO:0031667 IEA
    negative regulation of telomere maintenance GO:0032205 IMP
    cellular response to insulin stimulus GO:0032869 IEA
    regulation of intracellular estrogen receptor signaling pathway GO:0033146 IEA
    positive regulation of integrin activation GO:0033625 TAS
    regulation of toll-like receptor 3 signaling pathway GO:0034139 IDA
    adherens junction organization GO:0034332 IEA
    substrate adhesion-dependent cell spreading GO:0034446 IEA
    cellular response to reactive oxygen species GO:0034614 IMP
    positive regulation of dephosphorylation GO:0035306 IDA
    negative regulation of hippo signaling GO:0035331 IMP
    intracellular signal transduction GO:0035556 IDA
    osteoclast development GO:0036035 IEA
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEA
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    ERBB2 signaling pathway GO:0038128 TAS
    angiotensin-activated signaling pathway GO:0038166 ISS
    odontogenesis GO:0042476 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    negative regulation of apoptotic process GO:0043066 IMP
    regulation of vascular permeability GO:0043114 TAS
    stress fiber assembly GO:0043149 IMP
    transcytosis GO:0045056 IEA
    regulation of bone resorption GO:0045124 TAS
    bone resorption GO:0045453 ISS
    positive regulation of Notch signaling pathway GO:0045747 IDA
    positive regulation of bone resorption GO:0045780 IEA
    positive regulation of glycolytic process GO:0045821 IEA
    positive regulation of Ras protein signal transduction GO:0046579 IEA
    positive regulation of insulin receptor signaling pathway GO:0046628 IEA
    symbiont entry into host cell GO:0046718 TAS
    protein autophosphorylation GO:0046777 IDA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 IEA
    ephrin receptor signaling pathway GO:0048013 TAS
    focal adhesion assembly GO:0048041 IMP
    oogenesis GO:0048477 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IMP
    progesterone receptor signaling pathway GO:0050847 IBA
    progesterone receptor signaling pathway GO:0050847 ISS
    leukocyte migration GO:0050900 TAS
    positive regulation of small GTPase mediated signal transduction GO:0051057 IMP
    positive regulation of protein transport GO:0051222 IEA
    response to mineralocorticoid GO:0051385 IEA
    myoblast proliferation GO:0051450 IEA
    response to electrical stimulus GO:0051602 IEA
    negative regulation of focal adhesion assembly GO:0051895 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 TAS
    negative regulation of mitochondrial depolarization GO:0051902 IMP
    uterus development GO:0060065 IEA
    branching involved in mammary gland duct morphogenesis GO:0060444 IEA
    regulation of cell projection assembly GO:0060491 IEA
    intestinal epithelial cell development GO:0060576 IDA
    interleukin-6-mediated signaling pathway GO:0070102 IDA
    cellular response to hydrogen peroxide GO:0070301 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    response to interleukin-1 GO:0070555 IMP
    cellular response to lipopolysaccharide GO:0071222 IEA
    cellular response to peptide hormone stimulus GO:0071375 ISS
    cellular response to progesterone stimulus GO:0071393 ISS
    cellular response to fatty acid GO:0071398 IEA
    cellular response to hypoxia GO:0071456 IEA
    cellular response to fluid shear stress GO:0071498 IEA
    positive regulation of podosome assembly GO:0071803 IEA
    DNA biosynthetic process GO:0071897 IEA
    positive regulation of protein serine/threonine kinase activity GO:0071902 IDA
    regulation of heart rate by cardiac conduction GO:0086091 ISS
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    cell-cell adhesion GO:0098609 IEA
    positive regulation of protein localization to nucleus GO:1900182 IEA
    negative regulation of neutrophil activation GO:1902564 IDA
    positive regulation of TORC1 signaling GO:1904263 IDA
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IEA
    cellular response to prolactin GO:1990646 IEA
    negative regulation of cysteine-type endopeptidase activity GO:2000117 IMP
    positive regulation of male germ cell proliferation GO:2000256 IEA
    positive regulation of ovarian follicle development GO:2000386 IEA
    positive regulation of lamellipodium morphogenesis GO:2000394 IMP
    positive regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000588 IEA
    regulation of early endosome to late endosome transport GO:2000641 IMP
    negative regulation of anoikis GO:2000811 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IBA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IBA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IMP
    regulation of caveolin-mediated endocytosis GO:2001286 IMP
Subcellular Localization
    podosome GO:0002102 IEA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    lysosome GO:0005764 IDA
    late endosome GO:0005770 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    actin filament GO:0005884 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IDA
    cell-cell junction GO:0005911 IDA
    focal adhesion GO:0005925 ISS
    cell junction GO:0030054 IDA
    ruffle membrane GO:0032587 IEA
    neuronal cell body GO:0043025 IEA
    dendritic growth cone GO:0044294 IEA
    membrane raft GO:0045121 ISS
    perinuclear region of cytoplasm GO:0048471 IDA
    extracellular exosome GO:0070062 HDA
    synaptic membrane GO:0097060 IEA
    glutamatergic synapse GO:0098978 IEA
    postsynaptic specialization, intracellular component GO:0099091 IEA
    dendritic filopodium GO:1902737 IEA
 Experiment description of studies that identified SRC in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 282
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
12
Experiment ID 283
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
13
Experiment ID 286
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
14
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
15
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
21
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
22
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
23
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
25
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
28
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
29
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SRC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AXL 558
Far Western Homo sapiens
2 ARHGAP1 392
Reconstituted Complex Homo sapiens
3 IZUMO1  
Affinity Capture-MS Homo sapiens
4 UBL4A 8266
Affinity Capture-MS Homo sapiens
5 SHC1 6464
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
6 MATK  
Biochemical Activity Homo sapiens
7 ATG9A 79065
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
8 DAG1 1605
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
9 CRK 1398
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
10 IL36RN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MAP1LC3B 81631
Affinity Capture-Western Homo sapiens
12 HDAC3 8841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
13 HCK 3055
Affinity Capture-Western Homo sapiens
14 CDK2AP1  
Affinity Capture-MS Homo sapiens
15 SRC 6714
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
16 LHFPL2 10184
Affinity Capture-MS Homo sapiens
17 CRCP  
Affinity Capture-MS Homo sapiens
18 FBXO5  
Biochemical Activity Homo sapiens
19 PSMB9 5698
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
20 POLR2C 5432
Co-localization Homo sapiens
Co-localization Homo sapiens
21 Mbp 17196
Protein-peptide Mus musculus
22 ABHD17A 81926
Affinity Capture-MS Homo sapiens
23 DOCK1 1793
Affinity Capture-Western Homo sapiens
24 KIF14 9928
Affinity Capture-MS Homo sapiens
25 SORBS1 10580
Biochemical Activity Homo sapiens
26 CDKN1B 1027
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
27 C12orf4  
Affinity Capture-MS Homo sapiens
28 TMEM220  
Affinity Capture-MS Homo sapiens
29 FASLG 356
Protein-peptide Homo sapiens
30 TRIM7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
31 PDGFRB 5159
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 PLD1 5337
Biochemical Activity Homo sapiens
33 MCAM 4162
Proximity Label-MS Homo sapiens
34 CERS2 29956
Affinity Capture-MS Homo sapiens
35 CDH1 999
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 FYN 2534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
37 RASEF  
Affinity Capture-MS Homo sapiens
38 ENO1 2023
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
39 FLOT2 2319
Affinity Capture-MS Homo sapiens
40 SH2D2A  
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
41 ANLN 54443
Affinity Capture-MS Homo sapiens
42 MCOLN2  
Affinity Capture-MS Homo sapiens
43 ARHGAP32  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
44 C17orf78  
Affinity Capture-MS Homo sapiens
45 PRKCZ 5590
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 ERBB4 2066
Reconstituted Complex Homo sapiens
47 POLR2D  
Co-localization Homo sapiens
Co-localization Homo sapiens
48 FRMD5 84978
Affinity Capture-MS Homo sapiens
49 SDC2 6383
Affinity Capture-MS Homo sapiens
50 YTHDC1  
Affinity Capture-Western Homo sapiens
51 CCNL2 81669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 STAT1 6772
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 RPA3 6119
Proximity Label-MS Homo sapiens
54 MPZL1 9019
Affinity Capture-Western Homo sapiens
55 DAB2 1601
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
56 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
57 TRPV4 59341
Affinity Capture-Western Homo sapiens
58 AKT1 207
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
59 GPR113  
Affinity Capture-MS Homo sapiens
60 KCNA5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 Rapsn  
Biochemical Activity Mus musculus
62 CD46 4179
Biochemical Activity Homo sapiens
63 STUB1 10273
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
64 RASA1 5921
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
65 CDC25A  
Biochemical Activity Homo sapiens
66 GAB3  
Reconstituted Complex Homo sapiens
67 GRB2 2885
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
68 POLR2J  
Co-localization Homo sapiens
Co-localization Homo sapiens
69 DEFB114  
Affinity Capture-MS Homo sapiens
70 DEFB116  
Affinity Capture-MS Homo sapiens
71 CDC37 11140
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
72 PTPN2 5771
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
73 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 PDCD2 5134
Affinity Capture-MS Homo sapiens
75 TBK1 29110
Affinity Capture-Western Homo sapiens
76 SKAP1 8631
Reconstituted Complex Homo sapiens
77 RAB2A 5862
Proximity Label-MS Homo sapiens
78 RAB11A 8766
Proximity Label-MS Homo sapiens
79 EPHA2 1969
Proximity Label-MS Homo sapiens
80 ZNF641  
Affinity Capture-MS Homo sapiens
81 ISG20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 SYN1  
Affinity Capture-Western Homo sapiens
83 ANXA2 302
Co-fractionation Homo sapiens
84 USP32 84669
Affinity Capture-MS Homo sapiens
85 C1QL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 CTNND1 1500
Affinity Capture-Western Homo sapiens
87 TRAF1 7185
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
88 NCOA6  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
89 MAGEA3  
Affinity Capture-MS Homo sapiens
90 RASGRF1  
Biochemical Activity Homo sapiens
91 LAMP3  
Proximity Label-MS Homo sapiens
92 ADRB2  
Affinity Capture-Western Homo sapiens
93 SLC9A2  
Reconstituted Complex Homo sapiens
94 CORO7 79585
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
95 HSP90AB1 3326
Affinity Capture-Luminescence Homo sapiens
96 IFNGR1 3459
Affinity Capture-MS Homo sapiens
97 EVL 51466
Reconstituted Complex Homo sapiens
98 LRRC37A2  
Affinity Capture-MS Homo sapiens
99 SLC2A10  
Affinity Capture-MS Homo sapiens
100 LRP1 4035
Biochemical Activity Homo sapiens
101 RGS16 6004
Biochemical Activity Homo sapiens
102 C9orf156  
Affinity Capture-MS Homo sapiens
103 TLN1 7094
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
104 MUC1 4582
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
105 FGFR4 2264
Negative Genetic Homo sapiens
106 RNF133  
Affinity Capture-MS Homo sapiens
107 KHDRBS1 10657
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
108 SYK 6850
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
109 MICAL1 64780
Reconstituted Complex Homo sapiens
110 GAB2 9846
Affinity Capture-Western Homo sapiens
111 PLCG1 5335
Affinity Capture-Western Homo sapiens
112 PHF1  
Affinity Capture-Western Homo sapiens
113 CYSTM1 84418
Affinity Capture-MS Homo sapiens
114 FGFR1 2260
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 KDR  
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
116 SPG21 51324
Affinity Capture-MS Homo sapiens
117 CYP2S1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 CX3CL1  
Affinity Capture-MS Homo sapiens
119 CEP55 55165
Affinity Capture-MS Homo sapiens
120 PLSCR1 5359
Biochemical Activity Homo sapiens
121 MET 4233
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
122 LYN 4067
Protein-peptide Homo sapiens
123 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
124 RPS6KB1 6198
Biochemical Activity Homo sapiens
125 FBXL22  
Affinity Capture-MS Homo sapiens
126 XK  
Affinity Capture-MS Homo sapiens
127 PTK2B 2185
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
128 SPRR2A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
129 SRCIN1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
130 F2RL1  
Affinity Capture-MS Homo sapiens
131 PCDH20  
Affinity Capture-MS Homo sapiens
132 KCND3 3752
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
133 NDFIP2 54602
Affinity Capture-Western Homo sapiens
134 CAV2 858
Reconstituted Complex Homo sapiens
135 SCML1  
Affinity Capture-MS Homo sapiens
136 POLR2E 5434
Co-localization Homo sapiens
Co-localization Homo sapiens
137 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
138 PTK2 5747
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
139 COASY 80347
Biochemical Activity Homo sapiens
140 GAB1  
Reconstituted Complex Homo sapiens
141 LSMEM1  
Affinity Capture-MS Homo sapiens
142 RPS27 6232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 DMAP1 55929
Affinity Capture-MS Homo sapiens
144 FGFR2 2263
Affinity Capture-Western Homo sapiens
145 NLRP3  
Affinity Capture-Western Homo sapiens
146 FN3KRP 79672
Affinity Capture-MS Homo sapiens
147 PPARGC1B  
Reconstituted Complex Homo sapiens
148 HIST1H4F 8361
Affinity Capture-MS Homo sapiens
149 CCNA1  
Two-hybrid Homo sapiens
150 RHOB 388
Proximity Label-MS Homo sapiens
151 FYTTD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 PRUNE2  
Affinity Capture-MS Homo sapiens
153 SIRT3  
Affinity Capture-MS Homo sapiens
154 CBLC  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
155 CLPP 8192
Proximity Label-MS Homo sapiens
156 POLR2F  
Co-localization Homo sapiens
Co-localization Homo sapiens
157 RNF11 26994
Affinity Capture-MS Homo sapiens
158 TP53 7157
Biochemical Activity Homo sapiens
159 PDCD6IP 10015
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
160 FAS 355
Affinity Capture-Western Homo sapiens
161 PHF19  
Affinity Capture-MS Homo sapiens
162 HNRNPK 3190
Biochemical Activity Homo sapiens
163 ESR1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
164 EPHA3 2042
Reconstituted Complex Homo sapiens
165 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 ERRFI1 54206
Biochemical Activity Homo sapiens
167 UGT1A7 54577
Affinity Capture-MS Homo sapiens
168 ATP1A1 476
Affinity Capture-MS Homo sapiens
169 OSTF1 26578
Affinity Capture-Western Homo sapiens
170 GLRX3 10539
Affinity Capture-MS Homo sapiens
171 KRAS 3845
Proximity Label-MS Homo sapiens
172 NUP210P1  
Affinity Capture-MS Homo sapiens
173 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
174 BCAR1 9564
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
175 IKBKB 3551
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
176 LNX1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
177 MED28  
Affinity Capture-Western Homo sapiens
178 GUCA1B  
Affinity Capture-MS Homo sapiens
179 POLR2G 5436
Co-localization Homo sapiens
Co-localization Homo sapiens
180 PCDHGA5  
Affinity Capture-MS Homo sapiens
181 THRB 7068
Reconstituted Complex Homo sapiens
182 CA3 761
Two-hybrid Homo sapiens
183 CBLL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
184 PAK2 5062
Reconstituted Complex Homo sapiens
185 FLT3  
Reconstituted Complex Homo sapiens
186 SHB 6461
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
187 EPS8 2059
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
188 EGLN1 54583
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
189 PGR  
Two-hybrid Homo sapiens
190 RET 5979
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
191 RPS6KB2  
Biochemical Activity Homo sapiens
192 ZNF658B  
Affinity Capture-MS Homo sapiens
193 Adrb3  
Affinity Capture-Western Mus musculus
194 TYRO3 7301
Affinity Capture-Western Homo sapiens
195 IL10RB 3588
Positive Genetic Homo sapiens
196 IQGAP1 8826
Affinity Capture-Western Homo sapiens
197 STAT3 6774
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
198 PLD2 5338
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
199 FAM136A 84908
Affinity Capture-MS Homo sapiens
200 CRMP1 1400
Two-hybrid Homo sapiens
201 Chrna4  
Affinity Capture-Western Mus musculus
202 DDX4 54514
Affinity Capture-MS Homo sapiens
203 MAVS 57506
Affinity Capture-Western Homo sapiens
204 VDR  
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
205 C1QTNF9B  
Affinity Capture-MS Homo sapiens
206 LCN6  
Affinity Capture-MS Homo sapiens
207 NCSTN 23385
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 KCNA4  
Affinity Capture-Western Homo sapiens
209 ALOXE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 MAP2 4133
Reconstituted Complex Homo sapiens
211 HES3  
Affinity Capture-MS Homo sapiens
212 POLR2K  
Co-localization Homo sapiens
Co-localization Homo sapiens
213 MAPK8IP3  
Biochemical Activity Homo sapiens
214 TRGV3  
Affinity Capture-MS Homo sapiens
215 MANSC1 54682
Affinity Capture-MS Homo sapiens
216 KIT 3815
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
217 EFNA5  
Reconstituted Complex Homo sapiens
218 PTPRN2  
Affinity Capture-MS Homo sapiens
219 PTGS2 5743
Positive Genetic Homo sapiens
220 TSPAN3 10099
Affinity Capture-MS Homo sapiens
221 SKAP2 8935
Biochemical Activity Homo sapiens
222 USP8 9101
Biochemical Activity Homo sapiens
223 RAET1L  
Affinity Capture-MS Homo sapiens
224 MAPT  
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
225 SH3BP2  
Affinity Capture-Western Homo sapiens
226 NTRK1 4914
Affinity Capture-MS Homo sapiens
227 TMPRSS11E  
Affinity Capture-MS Homo sapiens
228 MAPK3 5595
Affinity Capture-Western Homo sapiens
229 S100B 6285
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
230 CIC 23152
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
231 PIK3R1 5295
Co-localization Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
232 BMX  
Affinity Capture-Western Homo sapiens
233 LATS2 26524
Biochemical Activity Homo sapiens
234 PECAM1 5175
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
235 NR1I3  
Two-hybrid Homo sapiens
236 ASAP2 8853
Affinity Capture-Western Homo sapiens
237 TMEM185A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
238 POLR2B 5431
Co-localization Homo sapiens
Co-localization Homo sapiens
239 SDHD  
Affinity Capture-MS Homo sapiens
240 ARHGAP17 55114
Reconstituted Complex Homo sapiens
241 HOXB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
242 NFKBIA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
243 PTPRA 5786
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
244 TRAF6 7189
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
245 NR3C1 2908
Protein-peptide Homo sapiens
246 EFS  
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
247 PTGER2  
Affinity Capture-Western Homo sapiens
248 PCDHGC3 5098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
249 GPAM 57678
Affinity Capture-MS Homo sapiens
250 PKD1 5310
Reconstituted Complex Homo sapiens
251 POLR2A 5430
Co-localization Homo sapiens
Co-localization Homo sapiens
252 GRASP  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
253 GRB10 2887
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
254 PROM1 8842
Biochemical Activity Homo sapiens
255 PCDH10 57575
Affinity Capture-MS Homo sapiens
256 RAB9A 9367
Proximity Label-MS Homo sapiens
257 CD244 51744
Affinity Capture-MS Homo sapiens
258 RAF1 5894
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
259 PARP1 142
Co-fractionation Homo sapiens
260 DHRS3 9249
Affinity Capture-MS Homo sapiens
261 ASAP1 50807
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
262 TLR4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
263 CHUK 1147
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
264 CSF1R  
Affinity Capture-Western Homo sapiens
265 SLC14A1  
Affinity Capture-MS Homo sapiens
266 HIF1A 3091
Co-localization Homo sapiens
267 RARA 5914
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
268 EDNRA 1909
Affinity Capture-Western Homo sapiens
269 PELP1 27043
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
270 EPHA4 2043
Reconstituted Complex Homo sapiens
271 KRT10 3858
Affinity Capture-MS Homo sapiens
272 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
273 CASP8 841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
274 EFNB1 1947
Biochemical Activity Homo sapiens
275 ABL1 25
Reconstituted Complex Homo sapiens
276 CREBBP  
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
277 ZDHHC23  
Affinity Capture-MS Homo sapiens
278 IL1R1 3554
Affinity Capture-Western Homo sapiens
279 KIFAP3 22920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
280 DDX58 23586
Affinity Capture-Western Homo sapiens
281 TLR9  
Affinity Capture-Western Homo sapiens
282 ACTA1 58
Affinity Capture-Western Homo sapiens
283 PDIK1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
284 KCNB1  
Biochemical Activity Homo sapiens
285 FLNA 2316
Two-hybrid Homo sapiens
286 STC2 8614
Affinity Capture-MS Homo sapiens
287 FMO5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
288 CD44 960
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
289 AR 367
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
290 RAC1 5879
Affinity Capture-Western Homo sapiens
291 VDAC3 7419
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
292 CAV1 857
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
293 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
294 ADRBK1 156
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
295 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
296 SLC29A1 2030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
297 CSK 1445
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
298 CD8B 926
Affinity Capture-MS Homo sapiens
299 S1PR2 9294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
300 PBK  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
301 RPL10 6134
Reconstituted Complex Homo sapiens
302 SOCS1  
Biochemical Activity Homo sapiens
303 LAMP2 3920
Proximity Label-MS Homo sapiens
304 DHX57 90957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
305 CFL1 1072
Biochemical Activity Homo sapiens
306 APP 351
Affinity Capture-Western Homo sapiens
307 ANKRD33  
Affinity Capture-MS Homo sapiens
308 WAS 7454
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
309 HIRIP3  
Affinity Capture-MS Homo sapiens
310 POLR2I 5438
Co-localization Homo sapiens
Co-localization Homo sapiens
311 SH3BP1 23616
Reconstituted Complex Homo sapiens
312 ZDHHC11  
Affinity Capture-MS Homo sapiens
313 ABCE1 6059
Affinity Capture-MS Homo sapiens
314 TOM1L1 10040
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
315 ALK 238
Affinity Capture-Western Homo sapiens
316 WASL 8976
Biochemical Activity Homo sapiens
317 DNM1 1759
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
318 CA14 23632
Affinity Capture-MS Homo sapiens
319 ERBB2 2064
Negative Genetic Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
320 NEDD4 4734
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
321 TRIM15  
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
322 LAMTOR1 55004
Proximity Label-MS Homo sapiens
323 USP22 23326
Affinity Capture-Western Homo sapiens
324 MAPK1 5594
Affinity Capture-Western Homo sapiens
325 DDR2 4921
Affinity Capture-Western Homo sapiens
326 TNFSF11  
Affinity Capture-Western Homo sapiens
327 PRDM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
328 RORC 6097
Affinity Capture-Western Homo sapiens
329 PDE6G  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
330 CEACAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
331 ND2 4536
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
332 ERBB3 2065
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
333 DOK1 1796
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
334 TMEM150A  
Affinity Capture-MS Homo sapiens
335 NONO 4841
Co-fractionation Homo sapiens
336 VSIG4  
Affinity Capture-MS Homo sapiens
337 PRDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
338 PAG1 55824
Affinity Capture-Western Homo sapiens
339 PTPN21 11099
Affinity Capture-Western Homo sapiens
340 VCL 7414
Co-fractionation Homo sapiens
341 S1PR1 1901
Affinity Capture-MS Homo sapiens
342 CENPM  
Affinity Capture-MS Homo sapiens
343 CHEK1  
Negative Genetic Homo sapiens
344 ITK 3702
Reconstituted Complex Homo sapiens
345 BRAF  
Positive Genetic Homo sapiens
346 GRIN2A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
347 DNM2 1785
Reconstituted Complex Homo sapiens
348 RABIF  
Affinity Capture-MS Homo sapiens
349 MYH4  
Affinity Capture-MS Homo sapiens
350 ZACN  
Affinity Capture-MS Homo sapiens
351 CLDN10  
Affinity Capture-MS Homo sapiens
352 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
353 HBG2 3048
Affinity Capture-MS Homo sapiens
354 POLR2H 5437
Co-localization Homo sapiens
Co-localization Homo sapiens
355 PDE4D  
Far Western Homo sapiens
356 ADRB3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
357 LAMP1 3916
Proximity Label-MS Homo sapiens
358 P2RY2 5029
Affinity Capture-Western Homo sapiens
359 Pde4d  
Affinity Capture-Western Rattus norvegicus
360 CEBPG  
Affinity Capture-MS Homo sapiens
361 ARF6 382
Proximity Label-MS Homo sapiens
362 BCCIP 56647
Biochemical Activity Homo sapiens
363 TRAF3 7187
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
364 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
365 RND3 390
Co-fractionation Homo sapiens
366 RNF212  
Affinity Capture-MS Homo sapiens
367 COX6B1 1340
Affinity Capture-MS Homo sapiens
368 ACBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
369 CLTC 1213
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
370 TRPC6 7225
Affinity Capture-Western Homo sapiens
371 MDM2  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
372 CCDC8  
Affinity Capture-MS Homo sapiens
373 GSN 2934
Affinity Capture-Western Homo sapiens
374 TMEM170A  
Affinity Capture-MS Homo sapiens
375 TRIP6 7205
Affinity Capture-Western Homo sapiens
376 SNCA 6622
Biochemical Activity Homo sapiens
377 TNK2 10188
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
378 ARRB2 409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
379 ESR2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
380 MYLK 4638
Affinity Capture-Western Homo sapiens
381 MIP  
Affinity Capture-MS Homo sapiens
382 POLR2L 5441
Co-localization Homo sapiens
Co-localization Homo sapiens
383 EPHB2 2048
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
384 FSD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
385 FCER1A  
Affinity Capture-MS Homo sapiens
386 GRM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
387 ADAM15 8751
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
388 BTBD2  
Affinity Capture-MS Homo sapiens
389 ARRB1 408
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
390 RXRA 6256
Reconstituted Complex Homo sapiens
391 PXN 5829
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
392 VIPR1  
Affinity Capture-MS Homo sapiens
393 GNB2L1 10399
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
394 PTGER4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
395 FBXL17  
Affinity Capture-MS Homo sapiens
396 KCNE4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SRC is involved
PathwayEvidenceSource
Activated NTRK2 signals through FYN IEA Reactome
Activated NTRK3 signals through PI3K IEA Reactome
Activated NTRK3 signals through PI3K TAS Reactome
Activation of NMDA receptors and postsynaptic events IEA Reactome
Adaptive Immune System TAS Reactome
ADP signalling through P2Y purinoceptor 1 TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Autophagy TAS Reactome
Axon guidance IEA Reactome
Axon guidance TAS Reactome
Bacterial Infection Pathways TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
CD28 co-stimulation TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Cell-Cell communication IEA Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Costimulation by the CD28 family TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
DCC mediated attractive signaling TAS Reactome
DCC mediated attractive signaling IEA Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of ERBB4 signaling TAS Reactome
Downstream signal transduction TAS Reactome
EPH-ephrin mediated repulsion of cells TAS Reactome
EPH-Ephrin signaling TAS Reactome
EPH-Ephrin signaling IEA Reactome
EPHA-mediated growth cone collapse TAS Reactome
EPHA-mediated growth cone collapse IEA Reactome
EPHB-mediated forward signaling TAS Reactome
EPHB-mediated forward signaling IEA Reactome
Ephrin signaling TAS Reactome
Ephrin signaling IEA Reactome
ESR-mediated signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR activation TAS Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
G alpha (i) signalling events TAS Reactome
G alpha (i) signalling events IEA Reactome
G alpha (s) signalling events TAS Reactome
G1 Phase TAS Reactome
GAB1 signalosome TAS Reactome
Gap junction trafficking and regulation TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
GP1b-IX-V activation signalling TAS Reactome
GPCR downstream signalling TAS Reactome
GPCR downstream signalling IEA Reactome
GPER1 signaling TAS Reactome
GRB2:SOS provides linkage to MAPK signaling for Integrins TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
InlA-mediated entry of Listeria monocytogenes into host cells TAS Reactome
Innate Immune System TAS Reactome
Integrin signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
L1CAM interactions TAS Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
Leishmania phagocytosis TAS Reactome
Listeria monocytogenes entry into host cells TAS Reactome
Long-term potentiation IEA Reactome
Macroautophagy TAS Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Membrane Trafficking TAS Reactome
MET activates PTK2 signaling TAS Reactome
MET promotes cell motility TAS Reactome
Mitophagy TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
NCAM signaling for neurite out-growth IEA Reactome
Negative regulation of FGFR1 signaling TAS Reactome
Negative regulation of FGFR2 signaling TAS Reactome
Negative regulation of FGFR3 signaling TAS Reactome
Negative regulation of FGFR4 signaling TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nervous system development IEA Reactome
Nervous system development TAS Reactome
Netrin mediated repulsion signals IEA Reactome
Netrin-1 signaling TAS Reactome
Netrin-1 signaling IEA Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Nuclear signaling by ERBB4 TAS Reactome
Oncogenic MAPK signaling TAS Reactome
p130Cas linkage to MAPK signaling for integrins TAS Reactome
p38MAPK events IEA Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
PECAM1 interactions TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Post NMDA receptor activation events IEA Reactome
RAF activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Receptor Mediated Mitophagy TAS Reactome
Recycling pathway of L1 TAS Reactome
Regulation of commissural axon pathfinding by SLIT and ROBO IEA Reactome
Regulation of gap junction activity TAS Reactome
Regulation of KIT signaling TAS Reactome
Regulation of RUNX1 Expression and Activity IEA Reactome
Regulation of RUNX3 expression and activity TAS Reactome
RET signaling TAS Reactome
RHO GTPase cycle IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate Formins TAS Reactome
RHOU GTPase cycle IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX2 regulates bone development IEA Reactome
RUNX2 regulates osteoblast differentiation IEA Reactome
Selective autophagy TAS Reactome
Signal amplification TAS Reactome
Signal regulatory protein family interactions IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK IEA Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by EGFR TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by MET TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRK3 (TRKC) IEA Reactome
Signaling by NTRK3 (TRKC) TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by PDGF TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by SCF-KIT IEA Reactome
Signaling by VEGF TAS Reactome
Signaling by VEGF IEA Reactome
Signaling downstream of RAS mutants TAS Reactome
Signalling to ERKs IEA Reactome
Signalling to RAS IEA Reactome
Spry regulation of FGF signaling TAS Reactome
Thrombin signalling through proteinase activated receptors (PARs) TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transcriptional regulation by RUNX3 TAS Reactome
Transmission across Chemical Synapses IEA Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated cell proliferation TAS Reactome
Vesicle-mediated transport TAS Reactome





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