Gene description for Ikbkb
Gene name	inhibitor of kappaB kinase beta
Gene symbol	Ikbkb
Other names/aliases	AI132552 IKK-2 IKK-beta IKK2 IKK[b] IKKbeta
Species	Mus musculus
Database cross references - Ikbkb
ExoCarta	ExoCarta_16150
Vesiclepedia	VP_16150
Entrez Gene	16150
UniProt	O88351
Ikbkb identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Ikbkb

Molecular Function     protein kinase activity GO:0004672 IDA     protein kinase activity GO:0004672 IMP     protein kinase activity GO:0004672 ISO     protein kinase activity GO:0004672 ISS     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 ISO     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     IkappaB kinase activity GO:0008384 IBA     IkappaB kinase activity GO:0008384 IDA     IkappaB kinase activity GO:0008384 IMP     IkappaB kinase activity GO:0008384 ISO     IkappaB kinase activity GO:0008384 ISO     protein kinase binding GO:0019901 ISO     protein phosphatase binding GO:0019903 IPI     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     protein-containing complex binding GO:0044877 ISO     protein heterodimerization activity GO:0046982 ISO     protein heterodimerization activity GO:0046982 ISS     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     scaffold protein binding GO:0097110 ISO     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA     transferrin receptor binding GO:1990459 ISO Biological Process     B cell homeostasis GO:0001782 IMP     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 ISO     integrin-mediated signaling pathway GO:0007229 IDA     canonical NF-kappaB signal transduction GO:0007249 IDA     canonical NF-kappaB signal transduction GO:0007249 IMP     canonical NF-kappaB signal transduction GO:0007249 ISO     I-kappaB phosphorylation GO:0007252 TAS     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of sodium ion transport GO:0010765 IGI     positive regulation of neuron projection development GO:0010976 ISO     peptidyl-serine phosphorylation GO:0018105 IDA     peptidyl-serine phosphorylation GO:0018105 ISO     cortical actin cytoskeleton organization GO:0030866 ISO     neuron projection development GO:0031175 ISO     tumor necrosis factor-mediated signaling pathway GO:0033209 IBA     tumor necrosis factor-mediated signaling pathway GO:0033209 IMP     tumor necrosis factor-mediated signaling pathway GO:0033209 ISO     tumor necrosis factor-mediated signaling pathway GO:0033209 TAS     regulation of phosphorylation GO:0042325 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     protein maturation GO:0051604 ISO     response to cholecystokinin GO:0061847 ISO     interleukin-1-mediated signaling pathway GO:0070498 ISO     cellular response to tumor necrosis factor GO:0071356 ISO     cellular response to tumor necrosis factor GO:0071356 ISS     protein localization to plasma membrane GO:0072659 ISO     regulation of establishment of endothelial barrier GO:1903140 ISO     negative regulation of bicellular tight junction assembly GO:1903347 ISO     positive regulation of cation channel activity GO:2001259 IGI Subcellular Localization     nucleus GO:0005634 IEA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 TAS     cytosol GO:0005829 ISO     IkappaB kinase complex GO:0008385 IBA     IkappaB kinase complex GO:0008385 IDA     IkappaB kinase complex GO:0008385 IPI     IkappaB kinase complex GO:0008385 ISO     cytoplasmic side of plasma membrane GO:0009898 IDA     CD40 receptor complex GO:0035631 IDA     membrane raft GO:0045121 IEA