Gene description for STX11
Gene name syntaxin 11
Gene symbol STX11
Other names/aliases FHL4
HLH4
HPLH4
Species Homo sapiens
 Database cross references - STX11
ExoCarta ExoCarta_8676
Vesiclepedia VP_8676
Entrez Gene 8676
HGNC 11429
MIM 605014
UniProt O75558  
 STX11 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for STX11
Molecular Function
    SNARE binding GO:0000149 IBA
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
Biological Process
    intracellular protein transport GO:0006886 IBA
    exocytosis GO:0006887 IBA
    synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 IBA
    vesicle docking GO:0048278 IBA
    membrane fusion GO:0061025 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    plasma membrane GO:0005886 IBA
    endomembrane system GO:0012505 IBA
    SNARE complex GO:0031201 IBA
    presynaptic active zone membrane GO:0048787 IBA
 Experiment description of studies that identified STX11 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for STX11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BLOC1S6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 SNAP23 8773
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SIKE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 HSBP1 3281
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TADA3  
Two-hybrid Homo sapiens
6 CTBP2 1488
Two-hybrid Homo sapiens
7 AES 166
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 CARD9 64170
Two-hybrid Homo sapiens
9 FKBP15 23307
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SMARCE1 6605
Two-hybrid Homo sapiens
11 BYSL 705
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 VAMP2 6844
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KIF7 374654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SNAP25 6616
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 STX4 6810
Two-hybrid Homo sapiens
16 STX11 8676
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 CDCA7L  
Two-hybrid Homo sapiens
19 CCNK  
Two-hybrid Homo sapiens
20 MBIP  
Two-hybrid Homo sapiens
21 NDE1 54820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RNPS1 10921
Two-hybrid Homo sapiens
23 STX1A 6804
Two-hybrid Homo sapiens
24 LRRC1 55227
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SOGA1 140710
Two-hybrid Homo sapiens
26 RNF8  
Two-hybrid Homo sapiens
27 LENG1  
Two-hybrid Homo sapiens
28 PPP1R18 170954
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 FAM110A  
Two-hybrid Homo sapiens
30 STX8 9482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MAGOHB 55110
Two-hybrid Homo sapiens
32 SUV39H1  
Two-hybrid Homo sapiens
33 RCBTB2  
Affinity Capture-MS Homo sapiens
34 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 CDR2L  
Two-hybrid Homo sapiens
36 USHBP1  
Two-hybrid Homo sapiens
37 MID2 11043
Two-hybrid Homo sapiens
38 STX6 10228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ZWINT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 STX10 8677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 LOH12CR1 118426
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PSMC3 5702
Two-hybrid Homo sapiens
43 KIF14 9928
Affinity Capture-MS Homo sapiens
44 VTI1A 143187
Affinity Capture-MS Homo sapiens
45 NUP155 9631
Affinity Capture-MS Homo sapiens
46 NDFIP1 80762
Affinity Capture-MS Homo sapiens
47 UBR4 23352
Affinity Capture-MS Homo sapiens
48 FARS2 10667
Two-hybrid Homo sapiens
49 LONRF1  
Two-hybrid Homo sapiens
50 TSGA10IP  
Two-hybrid Homo sapiens
51 KIFC3 3801
Two-hybrid Homo sapiens
52 FAM161B  
Two-hybrid Homo sapiens
53 GOLGA8F  
Two-hybrid Homo sapiens
54 ANKRD17 26057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 EXOC7 23265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 PDZRN3 23024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 GOLGA8EP  
Two-hybrid Homo sapiens
58 CCDC33 80125
Two-hybrid Homo sapiens
59 EIF2B5 8893
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
60 SCNM1  
Two-hybrid Homo sapiens
61 EXOC4 60412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 UBR5 51366
Affinity Capture-MS Homo sapiens
63 ANKHD1 54882
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 KLC3  
Two-hybrid Homo sapiens
65 WDYHV1  
Two-hybrid Homo sapiens
66 KRT75 9119
Two-hybrid Homo sapiens
67 EXOC6 54536
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 MEOX2  
Two-hybrid Homo sapiens
69 PKN1 5585
Two-hybrid Homo sapiens
70 PRPF18  
Two-hybrid Homo sapiens
71 KCMF1 56888
Affinity Capture-MS Homo sapiens
72 PTPRS 5802
Affinity Capture-MS Homo sapiens
73 PRPF31 26121
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
74 LINC00238  
Two-hybrid Homo sapiens
75 TAF6L 10629
Two-hybrid Homo sapiens
76 SNAP29 9342
Affinity Capture-MS Homo sapiens
77 DISC1 27185
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
78 PSMA3 5684
Two-hybrid Homo sapiens
79 STXBP5 134957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 VAMP8 8673
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 KCTD9  
Two-hybrid Homo sapiens
82 IKZF3  
Two-hybrid Homo sapiens
83 CCDC120  
Two-hybrid Homo sapiens
84 STXBP1 6812
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 MIS18A  
Two-hybrid Homo sapiens
86 VAMP3 9341
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 TCEA2  
Two-hybrid Homo sapiens
88 TRIM41 90933
Two-hybrid Homo sapiens
89 FAM90A1  
Two-hybrid Homo sapiens
90 HOXA1 3198
Two-hybrid Homo sapiens
91 AXIN2 8313
Two-hybrid Homo sapiens
92 RAD51D  
Two-hybrid Homo sapiens
93 RUNX1T1  
Two-hybrid Homo sapiens
94 NAPA 8775
Affinity Capture-MS Homo sapiens
95 MFAP1  
Two-hybrid Homo sapiens
96 CRYBA4  
Two-hybrid Homo sapiens
97 TNFRSF21 27242
Two-hybrid Homo sapiens
98 KAT5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 NDC80 10403
Two-hybrid Homo sapiens
100 ZNF587  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
101 SCNN1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 SHC3  
Two-hybrid Homo sapiens
103 PRKAB2 5565
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
104 PPFIA1 8500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 CCDC125 202243
Two-hybrid Homo sapiens
106 ZNF417  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 DUPD1  
Two-hybrid Homo sapiens
108 CCDC184  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
109 EXOC5 10640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 EIF1AD 84285
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
112 SLC38A2 54407
Two-hybrid Homo sapiens
113 HAUS1  
Two-hybrid Homo sapiens
114 SSFA2 6744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 UBASH3A 53347
Two-hybrid Homo sapiens
116 CCHCR1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
117 VPS52 6293
Two-hybrid Homo sapiens
118 GOSR1 9527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 ZNF19  
Two-hybrid Homo sapiens
120 IKBKG 8517
Two-hybrid Homo sapiens
121 VAMP4 8674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
123 CWF19L2  
Two-hybrid Homo sapiens
124 BRK1 55845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 TBK1 29110
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 KDM1A 23028
Two-hybrid Homo sapiens
127 TCF4  
Two-hybrid Homo sapiens
128 REPS1 85021
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 FAM161A  
Two-hybrid Homo sapiens
130 STXBP2 6813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 ZCCHC10  
Two-hybrid Homo sapiens
132 C1orf109  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
133 YKT6 10652
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 KXD1 79036
Two-hybrid Homo sapiens
135 CDR2  
Affinity Capture-MS Homo sapiens
136 FAM74A4  
Two-hybrid Homo sapiens
137 SH2D4A 63898
Two-hybrid Homo sapiens
138 MBD3L1  
Two-hybrid Homo sapiens
139 CCBE1 147372
Two-hybrid Homo sapiens
140 PCYT1A 5130
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which STX11 is involved
No pathways found





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