Gene description for JPH3
Gene name junctophilin 3
Gene symbol JPH3
Other names/aliases CAGL237
Species Homo sapiens
 Database cross references - JPH3
ExoCarta ExoCarta_57338
Entrez Gene 57338
HGNC 14203
MIM 605268
UniProt Q8WXH2  
 JPH3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for JPH3
Molecular Function
    molecular_function GO:0003674 ND
    calcium-release channel activity GO:0015278 IEA
Biological Process
    exploration behavior GO:0035640 IEA
    locomotion GO:0040011 IEA
    memory GO:0007613 IEA
    regulation of neuronal synaptic plasticity GO:0048168 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    learning GO:0007612 IEA
    calcium ion transport into cytosol GO:0060402 TAS
    neuromuscular process controlling balance GO:0050885 IEA
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 TAS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    junctional membrane complex GO:0030314 IEA
    junctional sarcoplasmic reticulum membrane GO:0014701 TAS
    integral component of membrane GO:0016021 NAS
 Experiment description of studies that identified JPH3 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for JPH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BGN 633
Reconstituted Complex Homo sapiens
2 STK24 8428
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JPH3 is involved
No pathways found

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