Gene description for GAS6
Gene name	growth arrest-specific 6
Gene symbol	GAS6
Other names/aliases	AXLLG AXSF
Species	Homo sapiens
Database cross references - GAS6
ExoCarta	ExoCarta_2621
Entrez Gene	2621
HGNC	4168
MIM	600441
UniProt	Q14393
GAS6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Mesenchymal stem cells	Unpublished / Not applicable
Nasopharyngeal carcinoma cells	25857718
Nasopharyngeal carcinoma cells	25857718
Nasopharyngeal carcinoma cells	25857718

Gene ontology annotations for GAS6

Molecular Function     receptor agonist activity GO:0048018 IDA     receptor tyrosine kinase binding GO:0030971 IPI     cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IDA     protein tyrosine kinase activator activity GO:0030296 IDA     protein binding GO:0005515 IPI     binding, bridging GO:0060090 IDA     calcium ion binding GO:0005509 IEA     voltage-gated calcium channel activity GO:0005245 IDA     receptor binding GO:0005102 IPI     phosphatidylserine binding GO:0001786 IDA Biological Process     negative regulation of renal albumin absorption GO:2000533 ISS     cell cycle arrest GO:0007050 TAS     signal transduction GO:0007165 TAS     protein targeting to plasma membrane GO:0072661 IDA     leukocyte migration GO:0050900 TAS     post-translational protein modification GO:0043687 TAS     phagocytosis GO:0006909 IDA     cellular response to interferon-alpha GO:0035457 IDA     cellular protein metabolic process GO:0044267 TAS     positive regulation of protein kinase B signaling GO:0051897 IDA     protein phosphorylation GO:0006468 IDA     cellular response to drug GO:0035690 IDA     negative regulation of interleukin-1 secretion GO:0050711 IDA     receptor-mediated virion attachment to host cell GO:0046813 IDA     fusion of virus membrane with host plasma membrane GO:0019064 IDA     protein kinase B signaling GO:0043491 IDA     negative regulation of fibroblast apoptotic process GO:2000270 IDA     positive regulation of dendritic cell chemotaxis GO:2000510 IDA     positive regulation of phagocytosis GO:0050766 IDA     negative regulation of biomineral tissue development GO:0070168 IDA     macrophage cytokine production GO:0010934 IEA     positive regulation of glomerular filtration GO:0003104 ISS     negative regulation of dendritic cell apoptotic process GO:2000669 IDA     positive regulation of cytokine-mediated signaling pathway GO:0001961 IMP     regulation of growth GO:0040008 IEA     viral genome replication GO:0019079 IDA     negative regulation of protein import into nucleus, translocation GO:0033159 IDA     cell migration GO:0016477 TAS     cell proliferation GO:0008283 TAS     hematopoietic stem cell migration to bone marrow GO:0097241 IDA     peptidyl-glutamic acid carboxylation GO:0017187 TAS     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IDA     positive regulation of TOR signaling GO:0032008 ISS     neuron migration GO:0001764 IEA     dendritic cell differentiation GO:0097028 IEP     activation of protein kinase B activity GO:0032148 ISS     apoptotic cell clearance GO:0043277 IDA     negative regulation of endothelial cell apoptotic process GO:2000352 IDA     negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IDA     cell-substrate adhesion GO:0031589 IEA     positive regulation of fibroblast proliferation GO:0048146 IDA     cellular response to growth factor stimulus GO:0071363 IEA     negative regulation of interferon-gamma production GO:0032689 IDA     negative regulation of tumor necrosis factor production GO:0032720 IDA     cell adhesion GO:0007155 TAS     viral entry into host cell GO:0046718 IDA     positive regulation of protein kinase activity GO:0045860 IDA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     B cell chemotaxis GO:0035754 IDA     organ regeneration GO:0031100 IEA     positive regulation of gene expression GO:0010628 IDA     platelet degranulation GO:0002576 TAS     cellular response to starvation GO:0009267 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     positive regulation of protein tyrosine kinase activity GO:0061098 IDA     enzyme linked receptor protein signaling pathway GO:0007167 IEA     cellular response to glucose stimulus GO:0071333 ISS     calcium ion transmembrane transport GO:0070588 IDA     platelet aggregation GO:0070527 TAS     peptidyl-serine phosphorylation GO:0018105 IDA     negative regulation of oligodendrocyte apoptotic process GO:1900142 IDA     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA     blood coagulation GO:0007596 TAS     positive regulation of protein phosphorylation GO:0001934 ISS     extracellular matrix assembly GO:0085029 ISS     cellular response to vitamin K GO:0071307 IDA     positive regulation of natural killer cell differentiation GO:0032825 IDA     negative regulation of interleukin-6 secretion GO:1900165 IDA     proteolysis GO:0006508 TAS     negative regulation of interleukin-6 production GO:0032715 IDA     platelet activation GO:0030168 TAS     negative regulation of transcription, DNA-templated GO:0045892 IDA     negative regulation of apoptotic process GO:0043066 IDA     positive regulation of protein export from nucleus GO:0046827 IDA Subcellular Localization     endoplasmic reticulum lumen GO:0005788 TAS     extracellular space GO:0005615 IDA     extracellular exosome GO:0070062 IDA     platelet alpha granule lumen GO:0031093 TAS     Golgi lumen GO:0005796 TAS     cytoplasm GO:0005737 IDA     extracellular region GO:0005576 TAS