Gene description for B4GAT1
Gene name beta-1,4-glucuronyltransferase 1
Gene symbol B4GAT1
Other names/aliases B3GN-T1
B3GNT1
B3GNT6
BETA3GNTI
MDDGA13
iGAT
iGNT
Species Homo sapiens
 Database cross references - B4GAT1
ExoCarta ExoCarta_11041
Vesiclepedia VP_11041
Entrez Gene 11041
HGNC 15685
MIM 605517
UniProt O43505  
 B4GAT1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for B4GAT1
Molecular Function
    protein binding GO:0005515 IPI
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity GO:0008532 IDA
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity GO:0008532 TAS
    glucuronosyltransferase activity GO:0015020 IBA
    glucuronosyltransferase activity GO:0015020 IDA
    glucuronosyltransferase activity GO:0015020 IMP
    metal ion binding GO:0046872 IEA
Biological Process
    axon guidance GO:0007411 IEA
    keratan sulfate biosynthetic process GO:0018146 TAS
    poly-N-acetyllactosamine biosynthetic process GO:0030311 IDA
    protein O-linked mannosylation GO:0035269 IBA
    protein O-linked mannosylation GO:0035269 IDA
Subcellular Localization
    Golgi membrane GO:0000139 NAS
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 IMP
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified B4GAT1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for B4GAT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CMTM6 54918
Affinity Capture-MS Homo sapiens
2 DERL2 51009
Affinity Capture-MS Homo sapiens
3 RNF167 26001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GJA1 2697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TMED4 222068
Affinity Capture-MS Homo sapiens
6 LPHN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NDUFB5 4711
Affinity Capture-MS Homo sapiens
8 BSCL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PLD4  
Affinity Capture-MS Homo sapiens
10 POM121  
Affinity Capture-MS Homo sapiens
11 ST7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PCBP3 54039
Affinity Capture-MS Homo sapiens
13 HSPA5 3309
Affinity Capture-MS Homo sapiens
14 PPP1CC 5501
Two-hybrid Homo sapiens
15 CHST10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ALG10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HYAL2 8692
Affinity Capture-MS Homo sapiens
18 ADCY6 112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 B4GALT7 11285
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TM9SF4 9777
Affinity Capture-MS Homo sapiens
21 TMED2 10959
Affinity Capture-MS Homo sapiens
22 CUX1 1523
Affinity Capture-MS Homo sapiens
23 TMEM201 199953
Affinity Capture-MS Homo sapiens
24 TMEM192 201931
Affinity Capture-MS Homo sapiens
25 NDUFAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 F2RL1  
Affinity Capture-MS Homo sapiens
27 LRFN1  
Affinity Capture-MS Homo sapiens
28 ABCC2 1244
Affinity Capture-MS Homo sapiens
29 POMT1 10585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GPRC5C 55890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ATP13A3 79572
Affinity Capture-MS Homo sapiens
32 TMEM59 9528
Affinity Capture-MS Homo sapiens
33 TMC6 11322
Affinity Capture-MS Homo sapiens
34 CHST12 55501
Affinity Capture-MS Homo sapiens
35 EIF2AK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 CNNM1  
Affinity Capture-MS Homo sapiens
37 CYP2S1  
Affinity Capture-MS Homo sapiens
38 POMGNT1 55624
Affinity Capture-MS Homo sapiens
39 CNNM4 26504
Affinity Capture-MS Homo sapiens
40 ATP8B2 57198
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SCAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 UGT8  
Affinity Capture-MS Homo sapiens
43 ATP9A 10079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 OGT 8473
Reconstituted Complex Homo sapiens
45 PIGT 51604
Affinity Capture-MS Homo sapiens
46 SLC47A1  
Affinity Capture-MS Homo sapiens
47 SGCB 6443
Affinity Capture-MS Homo sapiens
48 PISD  
Affinity Capture-MS Homo sapiens
49 S1PR1 1901
Affinity Capture-MS Homo sapiens
50 SUSD1 64420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CXCR4 7852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CANX 821
Affinity Capture-MS Homo sapiens
53 LEMD2 221496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 TMEM39B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 LRRC59 55379
Proximity Label-MS Homo sapiens
56 APOB 338
Affinity Capture-MS Homo sapiens
57 PTPRA 5786
Affinity Capture-MS Homo sapiens
58 FBXO6 26270
Affinity Capture-MS Homo sapiens
59 TMEM39A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 GYLTL1B 120071
Affinity Capture-MS Homo sapiens
61 SLC38A10 124565
Affinity Capture-MS Homo sapiens
62 HAPLN3 145864
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 EXT1 2131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 SLC7A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CNR2  
Affinity Capture-MS Homo sapiens
66 PPM1L 151742
Affinity Capture-MS Homo sapiens
67 FAR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 KCNN4 3783
Affinity Capture-MS Homo sapiens
69 KIDINS220 57498
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 GGCX 2677
Affinity Capture-MS Homo sapiens
71 B4GALT3 8703
Affinity Capture-MS Homo sapiens
72 PIGS 94005
Affinity Capture-MS Homo sapiens
73 SLC4A2 6522
Affinity Capture-MS Homo sapiens
74 TMEM87A 25963
Affinity Capture-MS Homo sapiens
75 TMED10 10972
Affinity Capture-MS Homo sapiens
76 TMEM57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 SNX25 83891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 GABRE  
Affinity Capture-MS Homo sapiens
79 XPR1 9213
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 FKRP 79147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 LMAN2L 81562
Affinity Capture-MS Homo sapiens
82 GPR107 57720
Affinity Capture-MS Homo sapiens
83 UNC93B1 81622
Affinity Capture-MS Homo sapiens
84 PTPN2 5771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ROR2 4920
Affinity Capture-MS Homo sapiens
86 FKTN  
Affinity Capture-MS Homo sapiens
87 HACD2 201562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 ITFG1 81533
Affinity Capture-MS Homo sapiens
89 SEC62 7095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 FAM69A 388650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 LPAR2 9170
Affinity Capture-MS Homo sapiens
92 ADGRE5 976
Affinity Capture-MS Homo sapiens
93 MAN1A2 10905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 THEM6  
Affinity Capture-MS Homo sapiens
95 ECSIT 51295
Affinity Capture-MS Homo sapiens
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