Gene description for FST
Gene name follistatin
Gene symbol FST
Other names/aliases FS
Species Homo sapiens
 Database cross references - FST
ExoCarta ExoCarta_10468
Entrez Gene 10468
HGNC 3971
MIM 136470
UniProt P19883  
 FST identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FST
Molecular Function
    signal transducer activity GO:0004871 NAS
    protein binding GO:0005515 IPI
    heparan sulfate proteoglycan binding GO:0043395 IEA
    activin binding GO:0048185 IPI
Biological Process
    keratinocyte proliferation GO:0043616 IEA
    pattern specification process GO:0007389 IEA
    BMP signaling pathway GO:0030509 IEA
    hair follicle morphogenesis GO:0031069 IEA
    positive regulation of hair follicle development GO:0051798 IDA
    negative regulation of cell differentiation GO:0045596 IEA
    female gonad development GO:0008585 IEA
    odontogenesis of dentin-containing tooth GO:0042475 IEA
    negative regulation of activin receptor signaling pathway GO:0032926 IDA
    gamete generation GO:0007276 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    hematopoietic progenitor cell differentiation GO:0002244 IDA
    skeletal system development GO:0001501 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified FST in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FST
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMP5  
Invivo Homo sapiens
2 TXN 7295
Two-hybrid Homo sapiens
3 INHBE  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which FST is involved
PathwayEvidenceSource
Antagonism of Activin by Follistatin TAS Reactome





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