Gene description for XXYLT1
Gene name xyloside xylosyltransferase 1
Gene symbol XXYLT1
Other names/aliases C3orf21
Species Homo sapiens
 Database cross references - XXYLT1
ExoCarta ExoCarta_152002
Vesiclepedia VP_152002
Entrez Gene 152002
HGNC 26639
MIM 614552
UniProt Q8NBI6  
 XXYLT1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for XXYLT1
Molecular Function
    magnesium ion binding GO:0000287 IDA
    manganese ion binding GO:0030145 IDA
    UDP-xylosyltransferase activity GO:0035252 IDA
    xylosyl alpha-1,3-xylosyltransferase activity GO:0140560 IBA
    xylosyl alpha-1,3-xylosyltransferase activity GO:0140560 IDA
Biological Process
    O-glycan processing GO:0016266 IBA
    O-glycan processing GO:0016266 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
 Experiment description of studies that identified XXYLT1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for XXYLT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPP1 4354
Affinity Capture-MS Homo sapiens
2 MLST8 64223
Affinity Capture-MS Homo sapiens
3 PRMT3 10196
Affinity Capture-MS Homo sapiens
4 Wdr82  
Affinity Capture-MS Mus musculus
5 MYCN  
Affinity Capture-MS Homo sapiens
6 TMED10 10972
Affinity Capture-MS Homo sapiens
7 IZUMO1  
Affinity Capture-MS Homo sapiens
8 FAM20C 56975
Affinity Capture-MS Homo sapiens
9 CANX 821
Affinity Capture-MS Homo sapiens
10 NOTCH2 4853
Affinity Capture-MS Homo sapiens
11 LRRC59 55379
Proximity Label-MS Homo sapiens
12 USP15 9958
Affinity Capture-MS Homo sapiens
13 PDCD2L 84306
Affinity Capture-MS Homo sapiens
14 NCAPH2  
Affinity Capture-MS Homo sapiens
15 SLC30A1 7779
Affinity Capture-MS Homo sapiens
16 RPA2 6118
Proximity Label-MS Homo sapiens
17 SPG21 51324
Affinity Capture-MS Homo sapiens
18 CUL3 8452
Affinity Capture-MS Homo sapiens
19 PLD4  
Affinity Capture-MS Homo sapiens
20 C17orf59 54785
Affinity Capture-MS Homo sapiens
21 CLYBL  
Affinity Capture-MS Homo sapiens
22 TNPO3 23534
Affinity Capture-MS Homo sapiens
23 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
24 TYSND1  
Affinity Capture-MS Homo sapiens
25 FAM63B 54629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 FFAR1  
Affinity Capture-MS Homo sapiens
27 NXF1 10482
Affinity Capture-RNA Homo sapiens
28 PLAA 9373
Affinity Capture-MS Homo sapiens
29 SAAL1 113174
Affinity Capture-MS Homo sapiens
30 MOV10 4343
Affinity Capture-RNA Homo sapiens
31 BCL2  
Affinity Capture-MS Homo sapiens
32 MYC  
Affinity Capture-MS Homo sapiens
33 RPA3 6119
Proximity Label-MS Homo sapiens
34 NDUFB8 4714
Affinity Capture-MS Homo sapiens
35 SHMT2 6472
Affinity Capture-RNA Homo sapiens
36 GXYLT1 283464
Affinity Capture-MS Homo sapiens
37 HTR1B  
Affinity Capture-MS Homo sapiens
38 DCP2  
Affinity Capture-MS Homo sapiens
39 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 HAUS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which XXYLT1 is involved
No pathways found





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