Gene description for COL5A1
Gene name collagen, type V, alpha 1
Gene symbol COL5A1
Other names/aliases EDSC
Species Homo sapiens
 Database cross references - COL5A1
ExoCarta ExoCarta_1289
Entrez Gene 1289
HGNC 2209
MIM 120215
UniProt P20908  
 COL5A1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for COL5A1
Molecular Function
    platelet-derived growth factor binding GO:0048407 IDA
    metal ion binding GO:0046872 IEA
    extracellular matrix structural constituent GO:0005201 IEA
    integrin binding GO:0005178 NAS
    heparin binding GO:0008201 IDA
    proteoglycan binding GO:0043394 IPI
Biological Process
    regulation of cellular component organization GO:0051128 IEA
    extracellular matrix organization GO:0030198 TAS
    collagen biosynthetic process GO:0032964 IMP
    cell adhesion GO:0007155 IMP
    extracellular fibril organization GO:0043206 IMP
    collagen fibril organization GO:0030199 NAS
    axon guidance GO:0007411 TAS
    tendon development GO:0035989 IEA
    extracellular matrix disassembly GO:0022617 TAS
    collagen catabolic process GO:0030574 TAS
    skin development GO:0043588 IMP
    integrin biosynthetic process GO:0045112 IMP
    negative regulation of endodermal cell differentiation GO:1903225 IDA
    cell migration GO:0016477 IMP
    blood vessel development GO:0001568 IEA
    eye morphogenesis GO:0048592 IMP
    heart morphogenesis GO:0003007 IEA
    wound healing, spreading of epidermal cells GO:0035313 IMP
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 TAS
    basement membrane GO:0005604 IEA
    extracellular matrix GO:0031012 IMP
    extracellular region GO:0005576 TAS
    collagen type V trimer GO:0005588 IMP
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified COL5A1 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for COL5A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 THBS1 7057
Invivo Homo sapiens
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
2 Igfbp7  
Affinity Capture-Western Mus musculus
3 COL5A3  
Invivo Homo sapiens
Invivo Homo sapiens
4 SPARC 6678
Reconstituted Complex Homo sapiens
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