Experiment description of studies that identified TTC3 in sEVs

1 Experiment ID 235 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name HKCI-8 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

2 Experiment ID 237 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocytes Sample name MIHA Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RNA Sequencing

Protein-protein interactions for TTC3

Protein Interactor ExoCarta ID Identification method PubMed Species 1 DSN1 79980 Affinity Capture-MS Homo sapiens 2 Bach1 12013 Affinity Capture-MS Mus musculus 3 HNRNPCL2 440563 Affinity Capture-MS Homo sapiens 4 HAX1   Proximity Label-MS Homo sapiens 5 Cul1 26965 Affinity Capture-MS Mus musculus 6 TNFRSF1B   Affinity Capture-MS Homo sapiens 7 Cit 12704 Two-hybrid Mus musculus 8 DYNC2LI1 51626 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 9 Tuba3a 22144 Affinity Capture-MS Mus musculus 10 UBE3A 7337 Two-hybrid Homo sapiens 11 Mad2l1bp   Affinity Capture-MS Mus musculus 12 ZCCHC10   Affinity Capture-MS Homo sapiens 13 ANAPC2 29882 Proximity Label-MS Homo sapiens 14 GARS 2617 Cross-Linking-MS (XL-MS) Homo sapiens 15 KRT8 3856 Proximity Label-MS Homo sapiens 16 UBE2E3 10477 Reconstituted Complex Homo sapiens 17 MEX3A   Affinity Capture-RNA Homo sapiens 18 RNF214   Affinity Capture-MS Homo sapiens 19 AKT3   Affinity Capture-Western Homo sapiens 20 CUL3 8452 Affinity Capture-MS Homo sapiens 21 SMC6   Affinity Capture-MS Homo sapiens 22 UBC 7316 Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 23 HSPB1 3315 Two-hybrid Homo sapiens 24 NPHP1   Affinity Capture-MS Homo sapiens 25 VHL   Two-hybrid Homo sapiens 26 CLSTN1 22883 Affinity Capture-MS Homo sapiens 27 DUSP16   Affinity Capture-MS Homo sapiens 28 EIF2B5 8893 Affinity Capture-MS Homo sapiens 29 WAPAL   Affinity Capture-MS Homo sapiens 30 Cep152   Affinity Capture-MS Mus musculus 31 Rassf1   Affinity Capture-MS Mus musculus 32 DNAJC7 7266 Proximity Label-MS Homo sapiens 33 APEX1 328 Affinity Capture-RNA Homo sapiens 34 UBE2D2 7322 Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 35 HSD17B7P2   Affinity Capture-MS Homo sapiens 36 CSNK2A2 1459 Affinity Capture-MS Homo sapiens 37 AKT2 208 Affinity Capture-Western Homo sapiens 38 Espn   Affinity Capture-MS Mus musculus 39 RAB5C 5878 Affinity Capture-MS Homo sapiens 40 PCM1 5108 Proximity Label-MS Homo sapiens 41 SMURF2 64750 Affinity Capture-Western Homo sapiens Biochemical Activity Homo sapiens Affinity Capture-Western Homo sapiens 42 DYNLL2 140735 Affinity Capture-MS Homo sapiens 43 SPANXN2   Affinity Capture-MS Homo sapiens 44 AKT1 207 Affinity Capture-Western Homo sapiens Biochemical Activity Homo sapiens Reconstituted Complex Homo sapiens 45 SRPK3   Affinity Capture-MS Homo sapiens 46 PARD6A   Affinity Capture-MS Homo sapiens 47 Pdlim5 56376 Affinity Capture-MS Mus musculus 48 LURAP1   Affinity Capture-MS Homo sapiens 49 FGFR1OP   Affinity Capture-MS Homo sapiens 50 SOX2   Affinity Capture-MS Homo sapiens 51 KRBOX4   Affinity Capture-MS Homo sapiens 52 KIF18A   Affinity Capture-MS Homo sapiens View the network

Pathways in which TTC3 is involved

No pathways found