Gene description for CDKN1B
Gene name	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene symbol	CDKN1B
Other names/aliases	CDKN4 KIP1 MEN1B MEN4 P27KIP1
Species	Homo sapiens
Database cross references - CDKN1B
ExoCarta	ExoCarta_1027
Vesiclepedia	VP_1027
Entrez Gene	1027
HGNC	1785
MIM	600778
UniProt	P46527
CDKN1B identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for CDKN1B

Molecular Function     protein kinase inhibitor activity GO:0004860 IMP     cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IBA     cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IDA     cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 TAS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IPI     protein phosphatase binding GO:0019903 IPI     cyclin-dependent protein kinase activating kinase regulator activity GO:0019914 EXP     cyclin binding GO:0030332 IPI     cyclin binding GO:0030332 ISS     Hsp70 protein binding GO:0030544 IEA     ubiquitin protein ligase binding GO:0031625 EXP     protein-containing complex binding GO:0044877 IPI     protein-folding chaperone binding GO:0051087 IBA     molecular adaptor activity GO:0060090 EXP     molecular function inhibitor activity GO:0140678 IMP     ubiquitin ligase activator activity GO:1990757 EXP Biological Process     regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 IDA     G1/S transition of mitotic cell cycle GO:0000082 IBA     G1/S transition of mitotic cell cycle GO:0000082 TAS     placenta development GO:0001890 IEA     potassium ion transport GO:0006813 IEA     DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS     regulation of exit from mitosis GO:0007096 IEA     Notch signaling pathway GO:0007219 IEA     heart development GO:0007507 ISS     sensory perception of sound GO:0007605 IEA     positive regulation of cell population proliferation GO:0008284 IEA     negative regulation of cell population proliferation GO:0008285 IMP     response to xenobiotic stimulus GO:0009410 IEA     response to glucose GO:0009749 IEA     negative regulation of cell growth GO:0030308 IDA     regulation of cell migration GO:0030334 IEA     positive regulation of microtubule polymerization GO:0031116 IEA     response to estradiol GO:0032355 IEA     negative regulation of kinase activity GO:0033673 IDA     negative regulation of phosphorylation GO:0042326 IDA     response to amino acid GO:0043200 IEA     response to peptide hormone GO:0043434 IEA     positive regulation of protein catabolic process GO:0045732 IDA     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IDA     positive regulation of DNA replication GO:0045740 TAS     negative regulation of DNA-templated transcription GO:0045892 IDA     negative regulation of mitotic cell cycle GO:0045930 IBA     response to cadmium ion GO:0046686 IEA     autophagic cell death GO:0048102 IDA     inner ear development GO:0048839 IEA     negative regulation of epithelial cell proliferation GO:0050680 IBA     nuclear export GO:0051168 IMP     regulation of cell cycle GO:0051726 IMP     regulation of cell cycle GO:0051726 ISS     epithelial cell proliferation involved in prostate gland development GO:0060767 IEA     negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 IEA     cellular response to antibiotic GO:0071236 IEA     cellular response to lithium ion GO:0071285 IDA     cellular response to organic cyclic compound GO:0071407 IEA     cellular response to hypoxia GO:0071456 IEA     cellular senescence GO:0090398 TAS     regulation of lens fiber cell differentiation GO:1902746 IEA     regulation of cell cycle G1/S phase transition GO:1902806 IMP     epithelial cell apoptotic process GO:1904019 IEA     negative regulation of cyclin-dependent protein kinase activity GO:1904030 IMP     negative regulation of epithelial cell apoptotic process GO:1904036 IEA     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IMP     negative regulation of cardiac muscle tissue regeneration GO:1905179 ISS     regulation of G1/S transition of mitotic cell cycle GO:2000045 IDA Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     endosome GO:0005768 IEA     cytosol GO:0005829 TAS     Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IDA     intracellular membrane-bounded organelle GO:0043231 IDA