Gene description for SIAE
Gene name sialic acid acetylesterase
Gene symbol SIAE
Other names/aliases AIS6
CSE-C
CSEC
LSE
YSG2
Species Homo sapiens
 Database cross references - SIAE
ExoCarta ExoCarta_54414
Vesiclepedia VP_54414
Entrez Gene 54414
HGNC 18187
MIM 610079
UniProt Q9HAT2  
 SIAE identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for SIAE
Molecular Function
    sialate O-acetylesterase activity GO:0001681 IBA
    sialate O-acetylesterase activity GO:0001681 IDA
    protein binding GO:0005515 IPI
    sialate 9-O-acetylesterase activity GO:0106330 IEA
Biological Process
    regulation of immune system process GO:0002682 IMP
    carbohydrate metabolic process GO:0005975 IBA
    carbohydrate metabolic process GO:0005975 IDA
Subcellular Localization
    extracellular space GO:0005615 HDA
    lysosome GO:0005764 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SIAE in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SIAE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCBLD2 131566
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SGSH 6448
Affinity Capture-MS Homo sapiens
3 MBTPS1 8720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MANEA 79694
Affinity Capture-MS Homo sapiens
5 MR1  
Affinity Capture-MS Homo sapiens
6 MANBA 4126
Affinity Capture-MS Homo sapiens
7 NPTX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 NAAA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GDF11 10220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TMEM30A 55754
Affinity Capture-MS Homo sapiens
11 CNTNAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MAN2B2 23324
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TCTN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 DEFB109P1B  
Affinity Capture-MS Homo sapiens
15 LAMB2 3913
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CTSF 8722
Affinity Capture-MS Homo sapiens
17 MANEAL 149175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NPTXR 23467
Affinity Capture-MS Homo sapiens
19 MOXD1 26002
Affinity Capture-MS Homo sapiens
20 TUBB8 347688
Affinity Capture-MS Homo sapiens
21 ARSB 411
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TUBB3 10381
Affinity Capture-MS Homo sapiens
23 FASTKD3  
Affinity Capture-MS Homo sapiens
24 CHSY3 337876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 COL18A1 80781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 LNPEP 4012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NRP2 8828
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 NAGLU 4669
Affinity Capture-MS Homo sapiens
30 KIAA1161 57462
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PLXNB2 23654
Affinity Capture-MS Homo sapiens
32 EDDM3A  
Affinity Capture-MS Homo sapiens
33 GALNT7 51809
Affinity Capture-MS Homo sapiens
34 POC1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 FAM162A 26355
Affinity Capture-MS Homo sapiens
36 PLTP 5360
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SEPN1 57190
Affinity Capture-MS Homo sapiens
38 TMEM132A 54972
Affinity Capture-MS Homo sapiens
39 DDX47 51202
Affinity Capture-MS Homo sapiens
40 FBXO2 26232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HLA-B 3106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ENTPD6  
Affinity Capture-MS Homo sapiens
43 COCH 1690
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PTPRK 5796
Affinity Capture-MS Homo sapiens
45 DNAJC3 5611
Affinity Capture-MS Homo sapiens
46 ERAP1 51752
Affinity Capture-MS Homo sapiens
47 TMEM2 23670
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 OAF 220323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 TGFBR3 7049
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 GALNS 2588
Affinity Capture-MS Homo sapiens
51 ARSK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TMEM131  
Affinity Capture-MS Homo sapiens
53 NDST2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RPP38 10557
Affinity Capture-MS Homo sapiens
55 GFPT2 9945
Affinity Capture-MS Homo sapiens
56 TENM3 55714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PTGFRN 5738
Affinity Capture-MS Homo sapiens
58 ADGRV1 84059
Affinity Capture-MS Homo sapiens
59 ITGA8 8516
Affinity Capture-MS Homo sapiens
60 CPE 1363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SIAE is involved
No pathways found





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