Gene description for SOX1
Gene name SRY (sex determining region Y)-box 1
Gene symbol SOX1
Other names/aliases -
Species Homo sapiens
 Database cross references - SOX1
ExoCarta ExoCarta_6656
Vesiclepedia VP_6656
Entrez Gene 6656
HGNC 11189
MIM 602148
UniProt O00570  
 SOX1 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SOX1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA binding GO:0003677 NAS
    DNA-binding transcription factor activity GO:0003700 NAS
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    lens morphogenesis in camera-type eye GO:0002089 IEA
    chromatin organization GO:0006325 NAS
    regulation of DNA-templated transcription GO:0006355 NAS
    brain development GO:0007420 IBA
    ventral spinal cord interneuron specification GO:0021521 IEA
    forebrain neuron development GO:0021884 IEA
    neuron differentiation GO:0030182 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    regulation of oligodendrocyte differentiation GO:0048713 ISS
    interneuron migration GO:1904936 ISS
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 NAS
 Experiment description of studies that identified SOX1 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SOX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFMBT1 51460
Affinity Capture-MS Homo sapiens
2 SOX5 6660
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CIAO1 9391
Affinity Capture-MS Homo sapiens
4 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here