Gene description for ACSL1
Gene name acyl-CoA synthetase long-chain family member 1
Gene symbol ACSL1
Other names/aliases ACS1
FACL1
FACL2
LACS
LACS1
LACS2
Species Homo sapiens
 Database cross references - ACSL1
ExoCarta ExoCarta_2180
Entrez Gene 2180
HGNC 3569
MIM 152425
UniProt P33121  
 ACSL1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Thymus 23844026    
 Gene ontology annotations for ACSL1
Molecular Function
    long-chain fatty acid-CoA ligase activity GO:0004467 TAS
    ATP binding GO:0005524 IEA
Biological Process
    xenobiotic catabolic process GO:0042178 IEA
    triglyceride biosynthetic process GO:0019432 TAS
    response to drug GO:0042493 IEA
    long-chain fatty acid import GO:0044539 IDA
    adiponectin-activated signaling pathway GO:0033211 IEA
    positive regulation of protein serine/threonine kinase activity GO:0071902 IEA
    unsaturated fatty acid metabolic process GO:0033559 TAS
    small molecule metabolic process GO:0044281 TAS
    cellular lipid metabolic process GO:0044255 TAS
    long-chain fatty acid metabolic process GO:0001676 IDA
    response to nutrient GO:0007584 IEA
    linoleic acid metabolic process GO:0043651 TAS
    response to organic cyclic compound GO:0014070 IEA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    response to oleic acid GO:0034201 IEA
    lipid biosynthetic process GO:0008610 IDA
    alpha-linolenic acid metabolic process GO:0036109 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 TAS
    plasma membrane GO:0005886 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
    peroxisomal membrane GO:0005778 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified ACSL1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACSL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here