Gene description for PTK2
Gene name protein tyrosine kinase 2
Gene symbol PTK2
Other names/aliases FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
Species Homo sapiens
 Database cross references - PTK2
ExoCarta ExoCarta_5747
Vesiclepedia VP_5747
Entrez Gene 5747
HGNC 9611
MIM 600758
UniProt Q05397  
 PTK2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PTK2
Molecular Function
    actin binding GO:0003779 IDA
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 ISS
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    protein tyrosine phosphatase activity GO:0004725 IMP
    integrin binding GO:0005178 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    JUN kinase binding GO:0008432 IDA
    protein kinase binding GO:0019901 IPI
    protein phosphatase binding GO:0019903 IPI
    histone H3Y41 kinase activity GO:0035401 IEA
    SH2 domain binding GO:0042169 IPI
    molecular function activator activity GO:0140677 EXP
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    angiogenesis GO:0001525 TAS
    placenta development GO:0001890 TAS
    regulation of protein phosphorylation GO:0001932 IGI
    positive regulation of protein phosphorylation GO:0001934 IMP
    heart morphogenesis GO:0003007 TAS
    chromatin remodeling GO:0006338 IEA
    signal complex assembly GO:0007172 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    integrin-mediated signaling pathway GO:0007229 IDA
    integrin-mediated signaling pathway GO:0007229 IMP
    integrin-mediated signaling pathway GO:0007229 TAS
    axon guidance GO:0007411 TAS
    positive regulation of cell population proliferation GO:0008284 ISS
    regulation of cell shape GO:0008360 IMP
    regulation of endothelial cell migration GO:0010594 TAS
    regulation of epithelial cell migration GO:0010632 IGI
    positive regulation of epithelial cell migration GO:0010634 IGI
    positive regulation of epithelial to mesenchymal transition GO:0010718 IGI
    positive regulation of macrophage chemotaxis GO:0010759 IGI
    positive regulation of fibroblast migration GO:0010763 IDA
    cell migration GO:0016477 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    negative regulation of cell-cell adhesion GO:0022408 IDA
    establishment of cell polarity GO:0030010 TAS
    regulation of cell adhesion GO:0030155 IBA
    positive regulation of cell migration GO:0030335 IBA
    positive regulation of cell migration GO:0030335 IDA
    regulation of cell adhesion mediated by integrin GO:0033628 IDA
    detection of muscle stretch GO:0035995 TAS
    netrin-activated signaling pathway GO:0038007 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    regulation of cell population proliferation GO:0042127 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    regulation of GTPase activity GO:0043087 TAS
    regulation of osteoblast differentiation GO:0045667 IMP
    positive regulation of protein kinase activity GO:0045860 IMP
    protein autophosphorylation GO:0046777 IDA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    ephrin receptor signaling pathway GO:0048013 IDA
    cell motility GO:0048870 TAS
    regulation of cytoskeleton organization GO:0051493 TAS
    regulation of focal adhesion assembly GO:0051893 IGI
    regulation of focal adhesion assembly GO:0051893 TAS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP
    growth hormone receptor signaling pathway GO:0060396 IDA
    positive regulation of wound healing GO:0090303 IDA
    positive regulation of macrophage proliferation GO:0120041 IGI
    regulation of substrate adhesion-dependent cell spreading GO:1900024 IGI
    positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 ISS
    negative regulation of anoikis GO:2000811 IMP
Subcellular Localization
    stress fiber GO:0001725 IDA
    nucleus GO:0005634 IDA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 TAS
    plasma membrane GO:0005886 IBA
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IDA
    cell cortex GO:0005938 IEA
    ciliary basal body GO:0036064 IDA
    dendritic spine GO:0043197 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified PTK2 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 256
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 258
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 258
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 259
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 260
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
Western blotting
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 ITGB1 3688
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
3 PTPN12 5782
Proximity Label-MS Homo sapiens
4 PPP1CB 5500
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 SHC1 6464
Affinity Capture-Western Homo sapiens
6 CSK 1445
Affinity Capture-Western Homo sapiens
7 TSC2 7249
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 ALMS1  
Proximity Label-MS Homo sapiens
9 DAG1 1605
Affinity Capture-Western Homo sapiens
10 ARHGAP26 23092
Reconstituted Complex Homo sapiens
11 CDH5  
Affinity Capture-Western Homo sapiens
12 CRK 1398
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
13 MTPAP 55149
Proximity Label-MS Homo sapiens
14 MAST4  
Proximity Label-MS Homo sapiens
15 APC  
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
16 LIMS1 3987
Co-fractionation Homo sapiens
17 RPL10 6134
Proximity Label-MS Homo sapiens
18 MAP4K4 9448
Proximity Label-MS Homo sapiens
19 GTPBP1 9567
Proximity Label-MS Homo sapiens
20 TRMT6 51605
Co-fractionation Homo sapiens
21 MUT 4594
Co-fractionation Homo sapiens
22 RET 5979
Co-localization Homo sapiens
23 STAP2 55620
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 AP3M1 26985
Proximity Label-MS Homo sapiens
26 GRB7 2886
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 NUDCD2 134492
Proximity Label-MS Homo sapiens
28 PTRH2 51651
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 BBS10  
Two-hybrid Homo sapiens
30 DIAPH1 1729
Co-fractionation Homo sapiens
31 TUBA1A 7846
Proximity Label-MS Homo sapiens
32 SOCS2  
Two-hybrid Homo sapiens
33 AGPAT3 56894
Affinity Capture-MS Homo sapiens
34 DEF6 50619
Two-hybrid Homo sapiens
35 TLN1 7094
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
36 WDR83  
Proximity Label-MS Homo sapiens
37 YES1 7525
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
38 IQGAP1 8826
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
39 SRC 6714
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
40 STAT3 6774
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
41 SYK 6850
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 SNRPD1 6632
Proximity Label-MS Homo sapiens
43 FER 2241
Co-fractionation Homo sapiens
44 PLCG1 5335
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
45 ITGA4 3676
Affinity Capture-Western Homo sapiens
46 WASL 8976
Co-fractionation Homo sapiens
47 Dctn5  
Affinity Capture-MS Mus musculus
48 VPS16 64601
Affinity Capture-MS Homo sapiens
49 SOCS3 9021
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
50 CBLB 868
Affinity Capture-Western Homo sapiens
51 NCK1 4690
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 RPL34 6164
Proximity Label-MS Homo sapiens
53 TRIM15  
PCA Homo sapiens
54 GSK3B 2932
Affinity Capture-Western Homo sapiens
55 CBL 867
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 RBM25 58517
Affinity Capture-MS Homo sapiens
57 MAPK1 5594
Co-fractionation Homo sapiens
58 F13A1 2162
Two-hybrid Homo sapiens
59 NEDD9 4739
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
60 MAPK8IP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 PPP1CA 5499
Affinity Capture-Western Homo sapiens
62 BCAR1 9564
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 SLC25A10 1468
Proximity Label-MS Homo sapiens
64 OFD1 8481
Proximity Label-MS Homo sapiens
65 BSPRY 54836
Affinity Capture-MS Homo sapiens
66 DDX39A 10212
Two-hybrid Homo sapiens
67 RB1CC1 9821
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
68 SAE1 10055
Two-hybrid Homo sapiens
69 IGF1R 3480
Affinity Capture-Western Homo sapiens
70 SHMT1 6470
Affinity Capture-MS Homo sapiens
71 LYN 4067
Affinity Capture-Western Homo sapiens
72 ILVBL 10994
Proximity Label-MS Homo sapiens
73 TEK  
Co-localization Homo sapiens
74 FAM193A  
Proximity Label-MS Homo sapiens
75 EPS8L2 64787
Two-hybrid Homo sapiens
76 RPL5 6125
Proximity Label-MS Homo sapiens
77 CEP152  
Proximity Label-MS Homo sapiens
78 RPL18A 6142
Proximity Label-MS Homo sapiens
79 CDH1 999
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
80 GIT1 28964
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
81 VCL 7414
Co-fractionation Homo sapiens
82 SWAP70 23075
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
83 ANKHD1-EIF4EBP3  
Proximity Label-MS Homo sapiens
84 NTRK1 4914
Affinity Capture-MS Homo sapiens
85 CRKL 1399
Co-localization Homo sapiens
86 CCR5 1234
Affinity Capture-Western Homo sapiens
87 TCHP  
Proximity Label-MS Homo sapiens
88 ACADM 34
Co-fractionation Homo sapiens
89 ERAL1  
Proximity Label-MS Homo sapiens
90 CIB1 10519
Affinity Capture-Western Homo sapiens
91 FLT1 2321
Co-localization Homo sapiens
92 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 TGM1 7051
Affinity Capture-MS Homo sapiens
94 FYN 2534
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
95 IARS 3376
Proximity Label-MS Homo sapiens
96 TRIM72  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
97 BMX  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
98 EPB41L5 57669
Proximity Label-MS Homo sapiens
99 ANKRD26 22852
Proximity Label-MS Homo sapiens
100 RBSN 64145
Affinity Capture-Western Homo sapiens
101 SRPK1 6732
Biochemical Activity Homo sapiens
102 CCDC18  
Proximity Label-MS Homo sapiens
103 NUDCD3 23386
Proximity Label-MS Homo sapiens
104 CACYBP 27101
Proximity Label-MS Homo sapiens
105 ACTN1 87
Co-fractionation Homo sapiens
106 PTPN11 5781
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 Tgfb1i1  
Affinity Capture-Western Mus musculus
108 SPATS2L 26010
Proximity Label-MS Homo sapiens
109 CXCR4 7852
Affinity Capture-Western Homo sapiens
110 NEO1 4756
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
111 RPL7A 6130
Proximity Label-MS Homo sapiens
112 PIP 5304
Affinity Capture-MS Homo sapiens
113 BAG2 9532
Affinity Capture-MS Homo sapiens
114 CTNNB1 1499
Co-fractionation Homo sapiens
115 ATG12  
Two-hybrid Homo sapiens
116 DOCK1 1793
Affinity Capture-Western Homo sapiens
117 RPL14 9045
Proximity Label-MS Homo sapiens
118 PTEN 5728
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
119 CTTN 2017
Affinity Capture-Western Homo sapiens
120 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
121 HES1 3280
Two-hybrid Homo sapiens
122 PTK2 5747
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
123 TGFB1I1 7041
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
124 KIAA1524 57650
Proximity Label-MS Homo sapiens
125 AMPH 273
Affinity Capture-Western Homo sapiens
126 FKBP5 2289
Affinity Capture-MS Homo sapiens
127 STAT1 6772
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 PIAS1 8554
Co-localization Homo sapiens
129 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
130 EEF1G 1937
Two-hybrid Homo sapiens
131 HSPA1A 3303
Affinity Capture-MS Homo sapiens
132 DCC  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
133 ERBB2 2064
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
134 CCNA1  
Co-localization Homo sapiens
135 KTN1 3895
Proximity Label-MS Homo sapiens
136 AKT1 207
Co-localization Homo sapiens
137 ASAP1 50807
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
138 MDM2  
Reconstituted Complex Homo sapiens
139 PTAFR  
Affinity Capture-Western Homo sapiens
140 STUB1 10273
Affinity Capture-Western Homo sapiens
141 GSN 2934
Affinity Capture-Western Homo sapiens
142 NASP 4678
Two-hybrid Homo sapiens
143 DVL2 1856
Co-fractionation Homo sapiens
144 TRIP6 7205
Affinity Capture-Western Homo sapiens
145 FGR 2268
Affinity Capture-Western Homo sapiens
146 MAP2K2 5605
Co-fractionation Homo sapiens
147 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
148 ZNF331  
Two-hybrid Homo sapiens
149 PARP1 142
Co-fractionation Homo sapiens
150 GRB2 2885
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
151 JUP 3728
Co-fractionation Homo sapiens
152 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
153 TUBG1 7283
Proximity Label-MS Homo sapiens
154 NACAD  
Two-hybrid Homo sapiens
155 PDCD6IP 10015
Affinity Capture-Western Homo sapiens
156 MISP 126353
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
157 EZR 7430
Reconstituted Complex Homo sapiens
158 CDC37 11140
Proximity Label-MS Homo sapiens
159 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
160 TSC1 7248
Affinity Capture-Western Homo sapiens
161 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
162 CDK6 1021
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
163 MAGEA9  
Affinity Capture-MS Homo sapiens
164 DDX58 23586
Affinity Capture-RNA Homo sapiens
165 OTUD6B 51633
Co-fractionation Homo sapiens
166 LPXN 9404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
167 NCK2 8440
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
168 ITGAV 3685
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
169 CEP131 22994
Proximity Label-MS Homo sapiens
170 GAPDH 2597
Co-fractionation Homo sapiens
171 BIN1 274
Affinity Capture-Western Homo sapiens
172 CDK4 1019
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
173 MND1  
Affinity Capture-MS Homo sapiens
174 PXN 5829
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
175 FBP1 2203
Two-hybrid Homo sapiens
176 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 RPL28 6158
Proximity Label-MS Homo sapiens
178 EPHA2 1969
Affinity Capture-Western Homo sapiens
179 NF2 4771
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
180 ITGB3 3690
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
181 CAMK2D 817
Proximity Label-MS Homo sapiens
182 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
183 RAC1 5879
Two-hybrid Homo sapiens
184 ITGB5 3693
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
185 JAK2 3717
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
186 IRS1 3667
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
187 PRKG1 5592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 PIK3R3 8503
Two-hybrid Homo sapiens
189 IFT74 80173
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PTK2 is involved
PathwayEvidenceSource
Apoptosis TAS Reactome
Apoptotic cleavage of cellular proteins TAS Reactome
Apoptotic execution phase TAS Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
Cell-Cell communication IEA Reactome
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to stimuli TAS Reactome
DCC mediated attractive signaling TAS Reactome
DCC mediated attractive signaling IEA Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
EPH-Ephrin signaling TAS Reactome
EPH-Ephrin signaling IEA Reactome
EPHB-mediated forward signaling TAS Reactome
EPHB-mediated forward signaling IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
GRB2:SOS provides linkage to MAPK signaling for Integrins TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Integrin signaling TAS Reactome
Leishmania infection TAS Reactome
Leishmania phagocytosis TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MET activates PTK2 signaling TAS Reactome
MET promotes cell motility TAS Reactome
NCAM signaling for neurite out-growth TAS Reactome
NCAM signaling for neurite out-growth IEA Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
Netrin-1 signaling TAS Reactome
Netrin-1 signaling IEA Reactome
p130Cas linkage to MAPK signaling for integrins TAS Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Programmed Cell Death TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
Response of endothelial cells to shear stress TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate WASPs and WAVEs TAS Reactome
Signal regulatory protein family interactions IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by MET TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by VEGF TAS Reactome
Signaling by VEGF IEA Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome





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