Gene description for CD8A
Gene name CD8a molecule
Gene symbol CD8A
Other names/aliases CD8
Species Homo sapiens
 Database cross references - CD8A
ExoCarta ExoCarta_925
Entrez Gene 925
HGNC 1706
MIM 186910
UniProt P01732  
 CD8A identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD8A
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
    MHC class I protein binding GO:0042288 NAS
    coreceptor activity GO:0015026 NAS
    protein homodimerization activity GO:0042803 IEA
Biological Process
    immune response GO:0006955 NAS
    antigen processing and presentation GO:0019882 NAS
    T cell mediated immunity GO:0002456 IEA
    defense response to virus GO:0051607 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 NAS
    cytotoxic T cell differentiation GO:0045065 IEA
    T cell activation GO:0042110 NAS
    regulation of immune response GO:0050776 TAS
    positive regulation of calcium-mediated signaling GO:0050850 IEA
Subcellular Localization
    external side of plasma membrane GO:0009897 IDA
    plasma membrane GO:0005886 TAS
    T cell receptor complex GO:0042101 NAS
    integral component of plasma membrane GO:0005887 NAS
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified CD8A in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD8A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD8A 925
Co-localization Homo sapiens
Co-crystal Structure Homo sapiens
Co-localization Homo sapiens
Co-crystal Structure Homo sapiens
2 LAT 27040
Invivo Homo sapiens
3 LGALS1 3956
Invitro Homo sapiens
4 PTPRC 5788
FRET Homo sapiens
5 CD3D 915
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
6 CD8B 926
Invivo Homo sapiens
Invitro Homo sapiens
Co-localization Homo sapiens
7 HLA-B  
Reconstituted Complex Homo sapiens
8 HLA-C 3107
Reconstituted Complex Homo sapiens
9 HLA-A  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
10 HLA-G  
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CD8A is involved
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TAS Reactome

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