Gene description for PABPC1L
Gene name poly(A) binding protein, cytoplasmic 1-like
Gene symbol PABPC1L
Other names/aliases C20orf119
PABPC1L1
dJ1069P2.3
ePAB
Species Homo sapiens
 Database cross references - PABPC1L
ExoCarta ExoCarta_80336
Vesiclepedia VP_80336
Entrez Gene 80336
HGNC 15797
UniProt Q4VXU2  
 PABPC1L identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PABPC1L
Molecular Function
    mRNA 3'-UTR binding GO:0003730 IBA
    poly(A) binding GO:0008143 IBA
    poly(U) RNA binding GO:0008266 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 IBA
    cytoplasmic stress granule GO:0010494 IBA
    extracellular exosome GO:0070062 HDA
    ribonucleoprotein complex GO:1990904 IBA
 Experiment description of studies that identified PABPC1L in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PABPC1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRC1 9055
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 PABPC1 26986
Cross-Linking-MS (XL-MS) Homo sapiens
4 AURKB 9212
Affinity Capture-MS Homo sapiens
5 PAIP2B  
Affinity Capture-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 GCM1  
Affinity Capture-MS Homo sapiens
8 GSPT2 23708
Affinity Capture-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 PABPC3 5042
Cross-Linking-MS (XL-MS) Homo sapiens
11 EFNA3  
Affinity Capture-MS Homo sapiens
12 TRIM11  
Affinity Capture-MS Homo sapiens
13 PARK2  
Affinity Capture-MS Homo sapiens
14 KIF14 9928
Affinity Capture-MS Homo sapiens
15 CYLD  
Affinity Capture-MS Homo sapiens
16 KIF23 9493
Affinity Capture-MS Homo sapiens
17 XPO1 7514
Affinity Capture-MS Homo sapiens
18 PABPC5 140886
Affinity Capture-MS Homo sapiens
19 ECT2 1894
Affinity Capture-MS Homo sapiens
20 PAIP1 10605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PABPC1L is involved
No pathways found





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