Gene description for FOCAD
Gene name focadhesin
Gene symbol FOCAD
Other names/aliases KIAA1797
Species Homo sapiens
 Database cross references - FOCAD
ExoCarta ExoCarta_54914
Vesiclepedia VP_54914
Entrez Gene 54914
HGNC 23377
MIM 614606
UniProt Q5VW36  
 FOCAD identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FOCAD
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of post-transcriptional gene silencing GO:0060147 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified FOCAD in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FOCAD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INSIG1  
Affinity Capture-MS Homo sapiens
2 GYPA  
Affinity Capture-MS Homo sapiens
3 IKBKAP 8518
Co-fractionation Homo sapiens
4 ZBTB2 57621
Affinity Capture-MS Homo sapiens
5 CYB5B 80777
Affinity Capture-MS Homo sapiens
6 DIDO1  
Affinity Capture-MS Homo sapiens
7 ZNF75A  
Affinity Capture-MS Homo sapiens
8 BTNL9  
Affinity Capture-MS Homo sapiens
9 PSENEN  
Affinity Capture-MS Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 NPTN 27020
Affinity Capture-MS Homo sapiens
12 ANAPC15  
Affinity Capture-MS Homo sapiens
13 CTTN 2017
Affinity Capture-MS Homo sapiens
14 TAS2R42  
Affinity Capture-MS Homo sapiens
15 COQ4  
Affinity Capture-MS Homo sapiens
16 RPL10 6134
Affinity Capture-MS Homo sapiens
17 HSPA4 3308
Co-fractionation Homo sapiens
18 CKAP2  
Affinity Capture-MS Homo sapiens
19 BNIP1 662
Affinity Capture-MS Homo sapiens
20 TMC4  
Affinity Capture-MS Homo sapiens
21 FTSJ3 117246
Affinity Capture-MS Homo sapiens
22 C20orf197  
Affinity Capture-MS Homo sapiens
23 AKR7L 246181
Affinity Capture-MS Homo sapiens
24 SLAIN2  
Affinity Capture-MS Homo sapiens
25 CTCFL  
Affinity Capture-MS Homo sapiens
26 PSPC1 55269
Affinity Capture-MS Homo sapiens
27 OR10H1  
Affinity Capture-MS Homo sapiens
28 NEDD1 121441
Affinity Capture-MS Homo sapiens
29 NTRK1 4914
Affinity Capture-MS Homo sapiens
30 GPR182  
Affinity Capture-MS Homo sapiens
31 Rrbp1  
Affinity Capture-MS Mus musculus
32 LINC00346  
Affinity Capture-MS Homo sapiens
33 NDC80 10403
Affinity Capture-MS Homo sapiens
34 RNF145  
Affinity Capture-MS Homo sapiens
35 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HNRNPU 3192
Affinity Capture-MS Homo sapiens
37 GNB2L1 10399
Affinity Capture-MS Homo sapiens
38 UBE2D3 7323
Two-hybrid Homo sapiens
39 Rpl35 66489
Affinity Capture-MS Mus musculus
40 VCL 7414
Affinity Capture-Western Homo sapiens
41 KLK12  
Affinity Capture-MS Homo sapiens
42 DNAJC22  
Affinity Capture-MS Homo sapiens
43 KIAA0408  
Affinity Capture-MS Homo sapiens
44 PMS2P3  
Affinity Capture-MS Homo sapiens
45 RAD21 5885
Affinity Capture-Western Homo sapiens
46 DDX55  
Affinity Capture-MS Homo sapiens
47 ZNF677  
Affinity Capture-MS Homo sapiens
48 RPS16 6217
Affinity Capture-MS Homo sapiens
49 C7orf49  
Affinity Capture-MS Homo sapiens
50 ZBTB44  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FOCAD is involved
No pathways found





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