Gene description for ACP6
Gene name acid phosphatase 6, lysophosphatidic
Gene symbol ACP6
Other names/aliases ACPL1
LPAP
PACPL1
Species Homo sapiens
 Database cross references - ACP6
ExoCarta ExoCarta_51205
Vesiclepedia VP_51205
Entrez Gene 51205
HGNC 29609
MIM 611471
UniProt Q9NPH0  
 ACP6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ACP6
Molecular Function
    acid phosphatase activity GO:0003993 IEA
    lysophosphatidic acid phosphatase activity GO:0052642 IBA
    lysophosphatidic acid phosphatase activity GO:0052642 IDA
    lysophosphatidic acid phosphatase activity GO:0052642 TAS
Biological Process
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    phospholipid metabolic process GO:0006644 IMP
    phosphatidic acid biosynthetic process GO:0006654 TAS
    lysobisphosphatidic acid metabolic process GO:2001311 IBA
    lysobisphosphatidic acid metabolic process GO:2001311 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified ACP6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ACP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ECH1 1891
Affinity Capture-MS Homo sapiens
2 PMPCB 9512
Affinity Capture-MS Homo sapiens
3 DHX36 170506
Affinity Capture-MS Homo sapiens
4 ACP6 51205
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DHCR7 1717
Affinity Capture-MS Homo sapiens
6 ABAT  
Co-fractionation Homo sapiens
7 BOLA3  
Affinity Capture-MS Homo sapiens
8 ERH 2079
Affinity Capture-MS Homo sapiens
9 STOML2 30968
Affinity Capture-MS Homo sapiens
10 SUCLG2 8801
Co-fractionation Homo sapiens
11 NME4 4833
Affinity Capture-MS Homo sapiens
12 FAM9B  
Two-hybrid Homo sapiens
13 RSU1 6251
Affinity Capture-MS Homo sapiens
14 LIMS1 3987
Affinity Capture-MS Homo sapiens
15 SUCLG1 8802
Co-fractionation Homo sapiens
16 ECI1 1632
Co-fractionation Homo sapiens
17 HMGCS1 3157
Co-fractionation Homo sapiens
18 SLC35F6 54978
Two-hybrid Homo sapiens
19 SUCLA2 8803
Co-fractionation Homo sapiens
20 NRD1 4898
Affinity Capture-MS Homo sapiens
21 PMPCA 23203
Affinity Capture-MS Homo sapiens
22 ANXA5 308
Co-fractionation Homo sapiens
23 CFL2 1073
Co-fractionation Homo sapiens
24 C1QBP 708
Affinity Capture-MS Homo sapiens
25 C9orf72  
Affinity Capture-MS Homo sapiens
26 ILK 3611
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 RGS10 6001
Affinity Capture-MS Homo sapiens
28 GNG7 2788
Two-hybrid Homo sapiens
29 CYCS 54205
Affinity Capture-MS Homo sapiens
30 ACN9  
Affinity Capture-MS Homo sapiens
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