Gene description for MVK
Gene name mevalonate kinase
Gene symbol MVK
Other names/aliases LRBP
MK
MVLK
POROK3
Species Homo sapiens
 Database cross references - MVK
ExoCarta ExoCarta_4598
Entrez Gene 4598
HGNC 7530
MIM 251170
UniProt Q03426  
 MVK identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MVK
Molecular Function
    ATP binding GO:0005524 IEA
    identical protein binding GO:0042802 IPI
    mevalonate kinase activity GO:0004496 TAS
Biological Process
    isoprenoid biosynthetic process GO:0008299 IDA
    cholesterol biosynthetic process GO:0006695 TAS
    phosphorylation GO:0016310 IEA
    negative regulation of inflammatory response GO:0050728 IMP
    isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 IEA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
    peroxisome GO:0005777 IDA
 Experiment description of studies that identified MVK in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MVK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MVK 4598
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 EWSR1 2130
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MVK is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) TAS Reactome
Cholesterol biosynthesis TAS Reactome





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