Gene description for CLEC3B
Gene name C-type lectin domain family 3, member B
Gene symbol CLEC3B
Other names/aliases TN
Species Homo sapiens
 Database cross references - CLEC3B
ExoCarta ExoCarta_7123
Entrez Gene 7123
HGNC 11891
MIM 187520
UniProt P05452  
 CLEC3B identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CLEC3B
Molecular Function
    kringle domain binding GO:0036143 IPI
    heparin binding GO:0008201 IDA
    calcium ion binding GO:0005509 IDA
    carbohydrate binding GO:0030246 IEA
Biological Process
    cellular response to transforming growth factor beta stimulus GO:0071560 IEP
    cellular response to organic substance GO:0071310 IEP
    skeletal system development GO:0001501 IEA
    bone mineralization GO:0030282 IEP
    positive regulation of plasminogen activation GO:0010756 ISS
    ossification GO:0001503 IEP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    extracellular matrix GO:0031012 ISS
    extracellular region GO:0005576 NAS
    granular component GO:0001652 IDA
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CLEC3B in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CLEC3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT18 3875
Affinity Capture-MS Homo sapiens
2 HGF 3082
Reconstituted Complex Homo sapiens
3 PLAT 5327
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
4 THRAP3 9967
Affinity Capture-MS Homo sapiens
5 PLG 5340
Invitro Homo sapiens
6 HSHIN1  
Affinity Capture-MS Homo sapiens
7 OSTF1 26578
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CLEC3B is involved
No pathways found

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