Gene description for Snrpd1
Gene name small nuclear ribonucleoprotein D1
Gene symbol Snrpd1
Other names/aliases AA407109
AL023031
SMD1
Species Mus musculus
 Database cross references - Snrpd1
ExoCarta ExoCarta_20641
Vesiclepedia VP_20641
Entrez Gene 20641
UniProt P62315  
 Snrpd1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snrpd1
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IEA
    U1 snRNP binding GO:1990446 IEA
    U1 snRNP binding GO:1990446 ISO
Biological Process
    spliceosomal snRNP assembly GO:0000387 IBA
    spliceosomal snRNP assembly GO:0000387 ISO
    spliceosomal snRNP assembly GO:0000387 ISS
    mRNA splicing, via spliceosome GO:0000398 ISO
    mRNA splicing, via spliceosome GO:0000398 ISS
Subcellular Localization
    commitment complex GO:0000243 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    spliceosomal complex GO:0005681 ISO
    U5 snRNP GO:0005682 IBA
    U2-type spliceosomal complex GO:0005684 ISO
    U2-type spliceosomal complex GO:0005684 ISS
    U1 snRNP GO:0005685 IBA
    U1 snRNP GO:0005685 ISO
    U1 snRNP GO:0005685 ISS
    U2 snRNP GO:0005686 IBA
    U4 snRNP GO:0005687 IBA
    U4 snRNP GO:0005687 ISO
    U4 snRNP GO:0005687 ISS
    U12-type spliceosomal complex GO:0005689 IEA
    U12-type spliceosomal complex GO:0005689 ISO
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    methylosome GO:0034709 ISO
    methylosome GO:0034709 ISS
    pICln-Sm protein complex GO:0034715 IBA
    pICln-Sm protein complex GO:0034715 ISO
    pICln-Sm protein complex GO:0034715 ISS
    SMN-Sm protein complex GO:0034719 IBA
    SMN-Sm protein complex GO:0034719 ISO
    SMN-Sm protein complex GO:0034719 ISS
    U4/U6 x U5 tri-snRNP complex GO:0046540 ISO
    U4/U6 x U5 tri-snRNP complex GO:0046540 ISS
    U2-type precatalytic spliceosome GO:0071005 ISO
    U2-type precatalytic spliceosome GO:0071005 ISS
    U2-type catalytic step 2 spliceosome GO:0071007 ISO
    U2-type catalytic step 2 spliceosome GO:0071007 ISS
    precatalytic spliceosome GO:0071011 IBA
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 ISO
    spliceosomal tri-snRNP complex GO:0097526 IBA
 Experiment description of studies that identified Snrpd1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snrpd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Strap 20901
Co-fractionation Mus musculus
2 Eif5 217869
Co-fractionation Mus musculus
3 Ssb 20823
Co-fractionation Mus musculus
4 Snrpe 20643
Co-fractionation Mus musculus
5 Sf3b1 81898
Co-fractionation Mus musculus
6 Atxn1  
Affinity Capture-MS Mus musculus
7 Rbm39 170791
Co-fractionation Mus musculus
8 Hdgf  
Co-fractionation Mus musculus
9 Kctd13  
Affinity Capture-MS Mus musculus
10 Snrpd2 107686
Co-fractionation Mus musculus
11 Sf3a1 67465
Co-fractionation Mus musculus
12 Ywhae 22627
Co-fractionation Mus musculus
13 Snrpd3 67332
Co-fractionation Mus musculus
14 Ppp1ca 19045
Co-fractionation Mus musculus
15 Sf3b3 101943
Co-fractionation Mus musculus
16 Hnrnph1 59013
Co-fractionation Mus musculus
17 Scly  
Co-fractionation Mus musculus
18 Lsm3  
Co-fractionation Mus musculus
19 Pabpc1 18458
Co-fractionation Mus musculus
20 Srsf1 110809
Co-fractionation Mus musculus
21 Srpk2 20817
Co-fractionation Mus musculus
22 Srrm2  
Co-fractionation Mus musculus
23 Syncrip 56403
Co-fractionation Mus musculus
24 Cops6 26893
Co-fractionation Mus musculus
25 Sfpq 71514
Co-fractionation Mus musculus
26 Dhx15 13204
Co-fractionation Mus musculus
27 Hnrnpa2b1 53379
Co-fractionation Mus musculus
28 Snrpa1 68981
Co-fractionation Mus musculus
29 Hnrnpk 15387
Co-fractionation Mus musculus
30 Ppil3  
Co-fractionation Mus musculus
31 Eed  
Affinity Capture-MS Mus musculus
32 Cwc27  
Co-fractionation Mus musculus
33 U2af2 22185
Co-fractionation Mus musculus
34 Mapt  
Affinity Capture-MS Mus musculus
35 Eftud2 20624
Co-fractionation Mus musculus
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