Gene description for Srpk2
Gene name serine/arginine-rich protein specific kinase 2
Gene symbol Srpk2
Other names/aliases AW226533
AW492537
AW547358
Wbp6
mSRPK2
Species Mus musculus
 Database cross references - Srpk2
ExoCarta ExoCarta_20817
Entrez Gene 20817
UniProt O54781  
 Srpk2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Srpk2
Molecular Function
    nucleotide binding GO:0000166 IEA
    14-3-3 protein binding GO:0071889 IDA
    protein serine/threonine kinase activity GO:0004674 ISO
    kinase activity GO:0016301 IEA
    poly(A) RNA binding GO:0044822 ISO
    transferase activity GO:0016740 IEA
    ATP binding GO:0005524 ISO
    protein kinase activity GO:0004672 IEA
    protein binding GO:0005515 IPI
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    magnesium ion binding GO:0000287 ISO
Biological Process
    cell differentiation GO:0030154 IEA
    intracellular signal transduction GO:0035556 ISO
    mRNA processing GO:0006397 IEA
    angiogenesis GO:0001525 IDA
    protein phosphorylation GO:0006468 ISO
    spliceosomal complex assembly GO:0000245 ISO
    nuclear speck organization GO:0035063 IDA
    negative regulation of viral genome replication GO:0045071 ISO
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of neuron apoptotic process GO:0043525 IDA
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of cell cycle GO:0045787 IDA
    positive regulation of viral genome replication GO:0045070 ISO
    RNA splicing GO:0008380 ISO
    phosphorylation GO:0016310 IEA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Srpk2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Srpk2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Srpk2 is involved
No pathways found





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