Gene description for INHBA
Gene name inhibin, beta A
Gene symbol INHBA
Other names/aliases EDF
FRP
Species Homo sapiens
 Database cross references - INHBA
ExoCarta ExoCarta_3624
Entrez Gene 3624
HGNC 6066
MIM 147290
UniProt P08476  
 INHBA identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for INHBA
Molecular Function
    peptide hormone binding GO:0017046 IPI
    identical protein binding GO:0042802 IPI
    protein heterodimerization activity GO:0046982 IEA
    growth factor activity GO:0008083 TAS
    hormone activity GO:0005179 TAS
    type II activin receptor binding GO:0070699 IPI
    cytokine activity GO:0005125 IDA
    protein binding GO:0005515 IPI
    transforming growth factor beta receptor binding GO:0005160 IBA
Biological Process
    negative regulation of phosphorylation GO:0042326 TAS
    hair follicle development GO:0001942 IGI
    positive regulation of cellular protein metabolic process GO:0032270 IDA
    cell differentiation GO:0030154 TAS
    positive regulation of erythrocyte differentiation GO:0045648 IDA
    erythrocyte differentiation GO:0030218 NAS
    hematopoietic progenitor cell differentiation GO:0002244 IDA
    ovarian follicle development GO:0001541 NAS
    G1/S transition of mitotic cell cycle GO:0000082 IDA
    eyelid development in camera-type eye GO:0061029 ISS
    mesodermal cell differentiation GO:0048333 IEA
    endodermal cell differentiation GO:0035987 IDA
    cell surface receptor signaling pathway GO:0007166 TAS
    male gonad development GO:0008584 IGI
    extrinsic apoptotic signaling pathway GO:0097191 IDA
    regulation of MAPK cascade GO:0043408 IBA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA
    negative regulation of cell proliferation GO:0008285 IDA
    negative regulation of B cell differentiation GO:0045578 TAS
    defense response GO:0006952 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    progesterone secretion GO:0042701 IGI
    nervous system development GO:0007399 NAS
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    SMAD protein signal transduction GO:0060395 IBA
    odontogenesis GO:0042476 IGI
    negative regulation of interferon-gamma biosynthetic process GO:0045077 TAS
    negative regulation of macrophage differentiation GO:0045650 TAS
    cell-cell signaling GO:0007267 TAS
    growth GO:0040007 IEA
    activin receptor signaling pathway GO:0032924 IDA
    negative regulation of follicle-stimulating hormone secretion GO:0046882 NAS
    positive regulation of follicle-stimulating hormone secretion GO:0046881 TAS
    palate development GO:0060021 IGI
    cellular response to cholesterol GO:0071397 IEA
    regulation of follicle-stimulating hormone secretion GO:0046880 IGI
    cell cycle arrest GO:0007050 IDA
    negative regulation of cell growth GO:0030308 IDA
    response to drug GO:0042493 IDA
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IEA
    cell development GO:0048468 IBA
    positive regulation of ovulation GO:0060279 ISS
    hemoglobin biosynthetic process GO:0042541 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IDA
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IDA
    negative regulation of cell cycle GO:0045786 IDA
Subcellular Localization
    activin A complex GO:0043509 IDA
    extracellular region GO:0005576 TAS
    cell GO:0005623 IGI
    extracellular space GO:0005615 IBA
    inhibin A complex GO:0043512 IDA
 Experiment description of studies that identified INHBA in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for INHBA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGFBP7 3490
Invitro Homo sapiens
Invivo Homo sapiens
2 INHA  
Affinity Capture-MS Homo sapiens
3 CHRDL2 25884
Reconstituted Complex Homo sapiens
4 ENG 2022
Affinity Capture-MS Homo sapiens
5 ACVR2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 ACVR1B 91
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 ACVR1 90
Affinity Capture-MS Homo sapiens
8 ACVR2B  
Affinity Capture-Western Homo sapiens
9 INHBA 3624
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 FSTL3  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which INHBA is involved
PathwayEvidenceSource
Antagonism of Activin by Follistatin TAS Reactome
Glycoprotein hormones TAS Reactome
Signaling by Activin TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here