Gene description for POLR2C
Gene name polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
Gene symbol POLR2C
Other names/aliases RPB3
RPB31
hRPB33
hsRPB3
Species Homo sapiens
 Database cross references - POLR2C
ExoCarta ExoCarta_5432
Vesiclepedia VP_5432
Entrez Gene 5432
HGNC 9189
MIM 180663
UniProt P19387  
 POLR2C identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for POLR2C
Molecular Function
    RNA polymerase II activity GO:0001055 IBA
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IEA
Biological Process
    transcription by RNA polymerase II GO:0006366 IBA
    transcription by RNA polymerase II GO:0006366 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    RNA polymerase II, core complex GO:0005665 IBA
    RNA polymerase II, core complex GO:0005665 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified POLR2C in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POLR2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Affinity Capture-MS Homo sapiens
2 POLR2G 5436
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 FAM208A  
Proximity Label-MS Homo sapiens
6 GTF2F1 2962
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
7 OTUD5 55593
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
8 TBK1 29110
Proximity Label-MS Homo sapiens
9 TPGS1  
Proximity Label-MS Homo sapiens
10 RNGTT 8732
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
11 NECAB2  
Two-hybrid Homo sapiens
12 CCT3 7203
Proximity Label-MS Homo sapiens
13 MED17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FAS 355
Proximity Label-MS Homo sapiens
15 MED20 9477
Affinity Capture-MS Homo sapiens
16 OFD1 8481
Proximity Label-MS Homo sapiens
17 PCF11 51585
Proximity Label-MS Homo sapiens
18 WWP1 11059
Affinity Capture-MS Homo sapiens
19 PGAM5 192111
Proximity Label-MS Homo sapiens
20 LLGL1 3996
Proximity Label-MS Homo sapiens
21 MED6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 Atf7ip  
Reconstituted Complex Mus musculus
23 Gtf2b  
Affinity Capture-MS Mus musculus
24 ZNHIT2 741
Proximity Label-MS Homo sapiens
25 MED29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 INTS10  
Affinity Capture-MS Homo sapiens
27 MED9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MED13L 23389
Affinity Capture-MS Homo sapiens
29 MAP4 4134
Co-fractionation Homo sapiens
30 TRIM33 51592
Affinity Capture-MS Homo sapiens
31 CCT4 10575
Proximity Label-MS Homo sapiens
32 UBC 7316
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
33 FAM168A  
Affinity Capture-MS Homo sapiens
34 EGLN1 54583
Proximity Label-MS Homo sapiens
35 FGF3  
Affinity Capture-MS Homo sapiens
36 KIF7 374654
Proximity Label-MS Homo sapiens
37 FKBP4 2288
Proximity Label-MS Homo sapiens
38 VPS54  
Proximity Label-MS Homo sapiens
39 SNRPF 6636
Affinity Capture-MS Homo sapiens
40 CEP97 79598
Proximity Label-MS Homo sapiens
41 URI1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
42 TCEA1 6917
Affinity Capture-MS Homo sapiens
43 TCEB3 6924
Co-localization Homo sapiens
Co-localization Homo sapiens
44 LMO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 MED13 9969
Affinity Capture-MS Homo sapiens
46 PFKL 5211
Proximity Label-MS Homo sapiens
47 PCNT  
Proximity Label-MS Homo sapiens
48 CNOT10 25904
Proximity Label-MS Homo sapiens
49 RPL28 6158
Proximity Label-MS Homo sapiens
50 GTF2F2 2963
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
51 HELZ 9931
Proximity Label-MS Homo sapiens
52 GPHN 10243
Proximity Label-MS Homo sapiens
53 POLR2I 5438
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 COPS5 10987
Affinity Capture-MS Homo sapiens
55 POLR3G  
Co-fractionation Homo sapiens
56 CCDC138  
Proximity Label-MS Homo sapiens
57 PHF3  
Proximity Label-MS Homo sapiens
58 SRC 6714
Co-localization Homo sapiens
Co-localization Homo sapiens
59 MDC1  
Affinity Capture-MS Homo sapiens
60 SNRPC 6631
Affinity Capture-MS Homo sapiens
61 MED27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 RPS9 6203
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
63 ABCE1 6059
Proximity Label-MS Homo sapiens
64 DLG5 9231
Proximity Label-MS Homo sapiens
65 EIF3E 3646
Affinity Capture-MS Homo sapiens
66 CRCP  
Affinity Capture-MS Homo sapiens
67 SULT1A2  
Proximity Label-MS Homo sapiens
68 MED22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
70 RBPJ 3516
Proximity Label-MS Homo sapiens
71 INTS6 26512
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
72 PSMB9 5698
Co-localization Homo sapiens
Co-localization Homo sapiens
73 ATG16L1 55054
Affinity Capture-MS Homo sapiens
74 POLR2C 5432
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
75 CLTC 1213
Proximity Label-MS Homo sapiens
76 UBE2W  
Two-hybrid Homo sapiens
77 RPL34 6164
Proximity Label-MS Homo sapiens
78 GPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 INTS12  
Affinity Capture-MS Homo sapiens
80 POLR2M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
81 SETD1A 9739
Proximity Label-MS Homo sapiens
82 ASNS 440
Proximity Label-MS Homo sapiens
83 CEP131 22994
Proximity Label-MS Homo sapiens
84 C14orf1 11161
Two-hybrid Homo sapiens
85 NEDD4 4734
Reconstituted Complex Homo sapiens
86 CCT5 22948
Proximity Label-MS Homo sapiens
87 SOD1 6647
Proximity Label-MS Homo sapiens
88 MTA2 9219
Co-fractionation Homo sapiens
89 RBM14 10432
Affinity Capture-MS Homo sapiens
90 Racgap1 26934
Affinity Capture-MS Mus musculus
91 KIF14 9928
Proximity Label-MS Homo sapiens
92 MED4 29079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 POLR1C 9533
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
95 POLR2K  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
96 MED1 5469
Affinity Capture-MS Homo sapiens
97 POLR1A 25885
Affinity Capture-MS Homo sapiens
98 CHMP4C 92421
Affinity Capture-MS Homo sapiens
99 PFKM 5213
Proximity Label-MS Homo sapiens
100 SRP9 6726
Affinity Capture-MS Homo sapiens
101 DLD 1738
Affinity Capture-MS Homo sapiens
102 TCP1 6950
Proximity Label-MS Homo sapiens
103 SCAF1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
104 MIB1 57534
Proximity Label-MS Homo sapiens
105 NUP62 23636
Proximity Label-MS Homo sapiens
106 MED7  
Affinity Capture-MS Homo sapiens
107 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
108 UXT 8409
Affinity Capture-MS Homo sapiens
109 CTDP1 9150
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
110 PSMC4 5704
Proximity Label-MS Homo sapiens
111 KLC1 3831
Affinity Capture-MS Homo sapiens
112 SCAF4 57466
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
113 DRG1 4733
Proximity Label-MS Homo sapiens
114 SUPT5H 6829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
115 MED18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 PSMC1 5700
Proximity Label-MS Homo sapiens
117 DNMT3A 1788
Affinity Capture-MS Homo sapiens
118 LRIF1  
Two-hybrid Homo sapiens
119 ATF4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
120 EPAS1  
Affinity Capture-MS Homo sapiens
121 GTF2H1 2965
Affinity Capture-MS Homo sapiens
122 SRRM2 23524
Proximity Label-MS Homo sapiens
123 CCT6A 908
Proximity Label-MS Homo sapiens
124 PFDN2 5202
Affinity Capture-MS Homo sapiens
125 DDX20 11218
Proximity Label-MS Homo sapiens
126 NELFE 7936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 HAUS8  
Proximity Label-MS Homo sapiens
128 CDK13 8621
Proximity Label-MS Homo sapiens
129 DCAF7 10238
Proximity Label-MS Homo sapiens
130 MED26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
131 CCP110  
Proximity Label-MS Homo sapiens
132 PPP2CA 5515
Affinity Capture-MS Homo sapiens
133 NFKBIA  
Two-hybrid Homo sapiens
134 PSMC2 5701
Proximity Label-MS Homo sapiens
135 EHBP1L1 254102
Co-fractionation Homo sapiens
136 CTR9 9646
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
137 IARS 3376
Proximity Label-MS Homo sapiens
138 L3MBTL2  
Proximity Label-MS Homo sapiens
139 MED31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 CDK9 1025
Proximity Label-MS Homo sapiens
141 ITCH 83737
Reconstituted Complex Homo sapiens
142 HAUS7  
Proximity Label-MS Homo sapiens
143 TUBAL3 79861
Proximity Label-MS Homo sapiens
144 PRKACB 5567
Affinity Capture-MS Homo sapiens
145 BRCA1 672
Affinity Capture-MS Homo sapiens
146 SMARCC2 6601
Two-hybrid Homo sapiens
147 POLR2B 5431
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
148 STUB1 10273
Proximity Label-MS Homo sapiens
149 PPP4R1 9989
Co-fractionation Homo sapiens
150 ZNF326 284695
Affinity Capture-Western Homo sapiens
151 ZCCHC8 55596
Proximity Label-MS Homo sapiens
152 RECQL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
153 KIF1B 23095
Proximity Label-MS Homo sapiens
154 ELP6 54859
Proximity Label-MS Homo sapiens
155 FAM76B  
Proximity Label-MS Homo sapiens
156 RBM39 9584
Affinity Capture-MS Homo sapiens
157 CDK19 23097
Affinity Capture-MS Homo sapiens
158 TAF15 8148
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
159 VPS53 55275
Proximity Label-MS Homo sapiens
160 FANCD2  
Affinity Capture-MS Homo sapiens
161 LEO1 123169
Affinity Capture-MS Homo sapiens
162 CDC73  
Proximity Label-MS Homo sapiens
163 POLR3A 11128
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
164 POLR2H 5437
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
165 RPS2 6187
Proximity Label-MS Homo sapiens
166 BAZ1B 9031
Affinity Capture-MS Homo sapiens
167 XPO1 7514
Affinity Capture-MS Homo sapiens
168 STIP1 10963
Proximity Label-MS Homo sapiens
169 BAG2 9532
Proximity Label-MS Homo sapiens
170 NELFCD 51497
Affinity Capture-MS Homo sapiens
171 SNRPB 6628
Affinity Capture-MS Homo sapiens
172 MYOG  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
173 POLR2E 5434
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
174 HNRNPR 10236
Co-fractionation Homo sapiens
175 TAB2  
Proximity Label-MS Homo sapiens
176 ASB6 140459
Affinity Capture-MS Homo sapiens
177 RPRD2  
Affinity Capture-MS Homo sapiens
178 C7orf76  
Affinity Capture-MS Homo sapiens
179 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 PCIF1 63935
Proximity Label-MS Homo sapiens
181 HAUS4  
Proximity Label-MS Homo sapiens
182 MECP2 4204
Affinity Capture-MS Homo sapiens
183 RPRD1A  
Affinity Capture-MS Homo sapiens
184 POLR2D  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 FUS 2521
Affinity Capture-MS Homo sapiens
186 RABGAP1 23637
Proximity Label-MS Homo sapiens
187 RPL7 6129
Proximity Label-MS Homo sapiens
188 POLR2A 5430
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
189 POLR3E 55718
Affinity Capture-MS Homo sapiens
190 FN1 2335
Affinity Capture-MS Homo sapiens
191 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
192 CDK5RAP2 55755
Proximity Label-MS Homo sapiens
193 EFTUD2 9343
Proximity Label-MS Homo sapiens
194 RPS27 6232
Proximity Label-MS Homo sapiens
195 PRMT5 10419
Affinity Capture-MS Homo sapiens
196 BIRC6 57448
Proximity Label-MS Homo sapiens
197 MAPK6  
Affinity Capture-MS Homo sapiens
198 MED10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 DNMT3B  
Affinity Capture-MS Homo sapiens
200 TADA2A  
Affinity Capture-MS Homo sapiens
201 POLR1E  
Affinity Capture-MS Homo sapiens
202 ZNRD1  
Affinity Capture-MS Homo sapiens
203 TOMM22 56993
Proximity Label-MS Homo sapiens
204 CCT8 10694
Proximity Label-MS Homo sapiens
205 TOP1 7150
Affinity Capture-MS Homo sapiens
206 CCT2 10576
Proximity Label-MS Homo sapiens
207 SCAF11  
Proximity Label-MS Homo sapiens
208 RPAP3 79657
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
209 DNM2 1785
Proximity Label-MS Homo sapiens
210 PSMC6 5706
Proximity Label-MS Homo sapiens
211 FLII 2314
Proximity Label-MS Homo sapiens
212 COPA 1314
Proximity Label-MS Homo sapiens
213 SLC25A11 8402
Proximity Label-MS Homo sapiens
214 STC2 8614
Two-hybrid Homo sapiens
215 SMC1A 8243
Proximity Label-MS Homo sapiens
216 FARSA 2193
Proximity Label-MS Homo sapiens
217 HSPA9 3313
Proximity Label-MS Homo sapiens
218 NELFB 25920
Affinity Capture-MS Homo sapiens
219 INTS5 80789
Affinity Capture-MS Homo sapiens
220 C9orf72  
Affinity Capture-MS Homo sapiens
221 MED14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 RPL15 6138
Proximity Label-MS Homo sapiens
223 NAA10 8260
Proximity Label-MS Homo sapiens
224 HUWE1 10075
Affinity Capture-MS Homo sapiens
225 EIF3D 8664
Proximity Label-MS Homo sapiens
226 EEF1A1 1915
Two-hybrid Homo sapiens
227 MED11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
228 RPL13 6137
Proximity Label-MS Homo sapiens
229 DHX15 1665
Affinity Capture-MS Homo sapiens
230 PRKAA1 5562
Proximity Label-MS Homo sapiens
231 NUDT21 11051
Two-hybrid Homo sapiens
232 MED19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 POLR2J  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
234 WNT1  
Affinity Capture-MS Homo sapiens
235 POLR2F  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
236 SIRT6  
Affinity Capture-MS Homo sapiens
237 DIDO1  
Proximity Label-MS Homo sapiens
238 WDR77 79084
Affinity Capture-MS Homo sapiens
239 C11orf58  
Two-hybrid Homo sapiens
240 TP53 7157
Negative Genetic Homo sapiens
Proximity Label-MS Homo sapiens
241 CDK8 1024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
242 GCOM1  
Affinity Capture-MS Homo sapiens
243 CCHCR1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
244 WWOX 51741
Affinity Capture-MS Homo sapiens
245 POLR2L 5441
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
246 POLR1B 84172
Affinity Capture-MS Homo sapiens
247 DNAJA2 10294
Proximity Label-MS Homo sapiens
248 PHRF1  
Affinity Capture-MS Homo sapiens
249 WDR92 116143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
250 POLR3H  
Affinity Capture-MS Homo sapiens
251 RPAP1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
252 CUL5 8065
Affinity Capture-MS Homo sapiens
253 SNRPA 6626
Affinity Capture-MS Homo sapiens
254 MED8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
255 CCNC  
Affinity Capture-MS Homo sapiens
256 SMURF1 57154
Affinity Capture-MS Homo sapiens
257 RPAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
258 YARS 8565
Proximity Label-MS Homo sapiens
259 NELFA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
260 RUVBL2 10856
Affinity Capture-MS Homo sapiens
261 HAUS5 23354
Proximity Label-MS Homo sapiens
262 RNF20 56254
Proximity Label-MS Homo sapiens
263 NUDT19 390916
Proximity Label-MS Homo sapiens
264 GEMIN4 50628
Proximity Label-MS Homo sapiens
265 POLR2J3  
Proximity Label-MS Homo sapiens
266 GTF2B 2959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
267 SCAF8 22828
Proximity Label-MS Homo sapiens
268 CCT7 10574
Proximity Label-MS Homo sapiens
269 RAD50 10111
Proximity Label-MS Homo sapiens
270 ESR1  
Co-localization Homo sapiens
Co-localization Homo sapiens
271 MED30  
Affinity Capture-MS Homo sapiens
272 ERCC3  
Affinity Capture-MS Homo sapiens
273 WWP2 11060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
274 ERCC6  
Affinity Capture-MS Homo sapiens
275 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
276 DNAAF5 54919
Proximity Label-MS Homo sapiens
277 MED12  
Affinity Capture-MS Homo sapiens
278 Rprd1b  
Affinity Capture-MS Mus musculus
279 PSMA5 5686
Affinity Capture-MS Homo sapiens
280 SUPT6H 6830
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
281 CAD 790
Proximity Label-MS Homo sapiens
282 POLR3D  
Affinity Capture-MS Homo sapiens
283 POLR3B 55703
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
284 RPRD1B 58490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
285 BRD1 23774
Affinity Capture-MS Homo sapiens
286 EIF2S3 1968
Proximity Label-MS Homo sapiens
287 PIH1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
288 INTS3 65123
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
289 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
290 RAB5C 5878
Proximity Label-MS Homo sapiens
291 POLR1D 51082
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
292 HAUS2  
Proximity Label-MS Homo sapiens
293 LRRC49  
Proximity Label-MS Homo sapiens
294 CAMK2D 817
Proximity Label-MS Homo sapiens
295 SSRP1 6749
Affinity Capture-MS Homo sapiens
296 CLP1  
Proximity Label-MS Homo sapiens
297 PHF8  
Affinity Capture-Western Homo sapiens
298 CPSF6 11052
Affinity Capture-MS Homo sapiens
299 PDRG1  
Affinity Capture-MS Homo sapiens
300 GPN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
301 MED28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
302 GTF2E2  
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which POLR2C is involved
PathwayEvidenceSource
Abortive elongation of HIV-1 transcript in the absence of Tat IEA Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Cell Cycle TAS Reactome
Chromosome Maintenance TAS Reactome
Developmental Biology IEA Reactome
Disease IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers IEA Reactome
DNA Repair TAS Reactome
Dual incision in TC-NER TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
FGFR2 alternative splicing TAS Reactome
FGFR2 mutant receptor activation IEA Reactome
Formation of HIV elongation complex in the absence of HIV Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat TAS Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat IEA Reactome
Formation of RNA Pol II elongation complex TAS Reactome
Formation of TC-NER Pre-Incision Complex TAS Reactome
Formation of the Early Elongation Complex TAS Reactome
Formation of the HIV-1 Early Elongation Complex IEA Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene Silencing by RNA IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
HIV elongation arrest and recovery IEA Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle IEA Reactome
HIV Life Cycle TAS Reactome
HIV Transcription Elongation TAS Reactome
HIV Transcription Elongation IEA Reactome
HIV Transcription Initiation IEA Reactome
Infectious disease IEA Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
Late Phase of HIV Life Cycle IEA Reactome
Late Phase of HIV Life Cycle TAS Reactome
Metabolism of RNA TAS Reactome
MicroRNA (miRNA) biogenesis TAS Reactome
mRNA Capping TAS Reactome
mRNA Splicing TAS Reactome
mRNA Splicing - Major Pathway TAS Reactome
mRNA Splicing - Minor Pathway TAS Reactome
Nucleotide Excision Repair TAS Reactome
Pausing and recovery of HIV elongation IEA Reactome
Pausing and recovery of Tat-mediated HIV elongation IEA Reactome
PIWI-interacting RNA (piRNA) biogenesis IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection IEA Reactome
RNA Polymerase II HIV Promoter Escape IEA Reactome
RNA Polymerase II Pre-transcription Events TAS Reactome
RNA Polymerase II Promoter Escape TAS Reactome
RNA polymerase II transcribes snRNA genes TAS Reactome
RNA polymerase II transcribes snRNA genes IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription Elongation TAS Reactome
RNA Polymerase II Transcription Initiation TAS Reactome
RNA Polymerase II Transcription Initiation And Promoter Clearance TAS Reactome
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAS Reactome
Signal Transduction TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease IEA Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 IIIa TM IEA Reactome
Signaling by FGFR2 in disease IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Tat-mediated elongation of the HIV-1 transcript TAS Reactome
Tat-mediated elongation of the HIV-1 transcript IEA Reactome
Tat-mediated HIV elongation arrest and recovery IEA Reactome
Telomere Maintenance TAS Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
Transcription of the HIV genome IEA Reactome
Transcription of the HIV genome TAS Reactome
Transcription-Coupled Nucleotide Excision Repair (TC-NER) TAS Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Infection Pathways TAS Reactome
Viral Messenger RNA Synthesis TAS Reactome





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