Gene description for BST1
Gene name bone marrow stromal cell antigen 1
Gene symbol BST1
Other names/aliases CD157
Species Homo sapiens
 Database cross references - BST1
ExoCarta ExoCarta_683
Entrez Gene 683
HGNC 1118
MIM 600387
UniProt Q10588  
 BST1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for BST1
Molecular Function
    phosphorus-oxygen lyase activity GO:0016849 IBA
    NAD(P)+ nucleosidase activity GO:0050135 IEA
    transferase activity GO:0016740 IEA
    NAD+ nucleosidase activity GO:0003953 IBA
Biological Process
    positive regulation of B cell proliferation GO:0030890 IBA
    humoral immune response GO:0006959 TAS
    metabolic process GO:0008152 IBA
    multicellular organismal development GO:0007275 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    anchored component of membrane GO:0031225 IEA
    extrinsic component of membrane GO:0019898 TAS
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified BST1 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 274
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for BST1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BST1 683
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
View the network image/svg+xml
 Pathways in which BST1 is involved
No pathways found





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