Gene description for CCL2
Gene name	chemokine (C-C motif) ligand 2
Gene symbol	CCL2
Other names/aliases	GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF
Species	Homo sapiens
Database cross references - CCL2
ExoCarta	ExoCarta_6347
Entrez Gene	6347
HGNC	10618
MIM	158105
UniProt	P13500
CCL2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for CCL2

Molecular Function     protein kinase activity GO:0004672 TAS     receptor binding GO:0005102 TAS     chemokine activity GO:0008009 IEA     heparin binding GO:0008201 IEA     CCR2 chemokine receptor binding GO:0031727 TAS Biological Process     maternal process involved in female pregnancy GO:0060135 IEA     maternal process involved in parturition GO:0060137 IEA     G-protein coupled receptor signaling pathway GO:0007186 TAS     negative regulation of neuron apoptotic process GO:0043524 IDA     chemotaxis GO:0006935 TAS     negative regulation of natural killer cell chemotaxis GO:2000502 IDA     MAPK cascade GO:0000165 IMP     positive regulation of leukocyte mediated cytotoxicity GO:0001912 IEA     cellular response to interleukin-1 GO:0071347 ISS     cell surface receptor signaling pathway GO:0007166 TAS     monocyte chemotaxis GO:0002548 IDA     response to vitamin B3 GO:0033552 IEA     cellular response to insulin stimulus GO:0032869 IEA     response to ethanol GO:0045471 IEA     positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 IEA     aging GO:0007568 IEA     cellular response to fibroblast growth factor stimulus GO:0044344 IEP     response to wounding GO:0009611 IEA     leukocyte migration involved in inflammatory response GO:0002523 IEA     cell adhesion GO:0007155 TAS     cellular response to tumor necrosis factor GO:0071356 ISS     transforming growth factor beta receptor signaling pathway GO:0007179 IEA     inflammatory response GO:0006954 IDA     positive regulation of cellular extravasation GO:0002693 IEA     positive regulation of tumor necrosis factor production GO:0032760 IEA     macrophage chemotaxis GO:0048246 IDA     cellular homeostasis GO:0019725 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 IEA     cellular response to ATP GO:0071318 IEA     cytokine-mediated signaling pathway GO:0019221 IDA     regulation of vascular endothelial growth factor production GO:0010574 IEA     lipopolysaccharide-mediated signaling pathway GO:0031663 IDA     positive regulation of endothelial cell proliferation GO:0001938 IEA     viral genome replication GO:0019079 TAS     positive regulation of T cell activation GO:0050870 ISS     response to amino acid GO:0043200 IEA     cellular calcium ion homeostasis GO:0006874 IEA     positive regulation of calcium ion import GO:0090280 IDA     cellular response to interferon-gamma GO:0071346 ISS     organ morphogenesis GO:0009887 TAS     positive regulation of apoptotic cell clearance GO:2000427 ISS     astrocyte cell migration GO:0043615 IDA     negative regulation of angiogenesis GO:0016525 IEA     response to activity GO:0014823 IEA     cellular protein metabolic process GO:0044267 TAS     cellular response to lipopolysaccharide GO:0071222 ISS     positive regulation of macrophage chemotaxis GO:0010759 IEA     response to mechanical stimulus GO:0009612 IEA     PERK-mediated unfolded protein response GO:0036499 TAS     negative regulation of glial cell apoptotic process GO:0034351 IDA     cellular response to organic cyclic compound GO:0071407 IDA     positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 ISS     cytoskeleton organization GO:0007010 IDA     response to bacterium GO:0009617 NAS     endoplasmic reticulum unfolded protein response GO:0030968 TAS     response to progesterone GO:0032570 IEA     neutrophil chemotaxis GO:0030593 IEA     organ regeneration GO:0031100 IEA     response to hypoxia GO:0001666 IEA     cellular response to dexamethasone stimulus GO:0071549 IEA     cellular response to retinoic acid GO:0071300 IEA     positive regulation of synaptic transmission GO:0050806 IEA     JAK-STAT cascade GO:0007259 TAS     cellular response to platelet-derived growth factor stimulus GO:0036120 IEA     response to gamma radiation GO:0010332 IEA     chemokine-mediated signaling pathway GO:0070098 IEA     cellular response to drug GO:0035690 IEA     positive regulation of collagen biosynthetic process GO:0032967 IEA     lymphocyte chemotaxis GO:0048247 IEA     response to antibiotic GO:0046677 IEA     humoral immune response GO:0006959 TAS     helper T cell extravasation GO:0035684 ISS     cellular response to macrophage colony-stimulating factor stimulus GO:0036006 IEA     signal transduction GO:0007165 NAS     regulation of cell shape GO:0008360 IDA     positive regulation of monocyte chemotaxis GO:0090026 IEA     protein phosphorylation GO:0006468 TAS     cellular response to interleukin-6 GO:0071354 IEA     response to heat GO:0009408 IEA     cellular response to high density lipoprotein particle stimulus GO:0071403 IEA     protein kinase B signaling GO:0043491 IMP     angiogenesis GO:0001525 TAS     G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS Subcellular Localization     axon terminus GO:0043679 IEA     extracellular space GO:0005615 IEA     rough endoplasmic reticulum GO:0005791 IEA     extracellular region GO:0005576 TAS     C-fiber GO:0044299 IEA     perikaryon GO:0043204 IEA     endocytic vesicle GO:0030139 IEA     dendrite GO:0030425 IEA     synapse GO:0045202 IEA     perinuclear region of cytoplasm GO:0048471 IEA