Gene description for CXCL8
Gene name chemokine (C-X-C motif) ligand 8
Gene symbol CXCL8
Other names/aliases GCP-1
Species Homo sapiens
 Database cross references - CXCL8
ExoCarta ExoCarta_3576
Entrez Gene 3576
HGNC 6025
MIM 146930
UniProt P10145  
 CXCL8 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CXCL8
Molecular Function
    interleukin-8 receptor binding GO:0005153 IPI
    chemokine activity GO:0008009 TAS
    protein binding GO:0005515 IPI
Biological Process
    immune response GO:0006955 IBA
    PERK-mediated unfolded protein response GO:0036499 TAS
    inflammatory response GO:0006954 TAS
    intracellular signal transduction GO:0035556 IDA
    receptor internalization GO:0031623 IDA
    positive regulation of angiogenesis GO:0045766 IDA
    response to molecule of bacterial origin GO:0002237 IDA
    calcium-mediated signaling GO:0019722 TAS
    G-protein coupled receptor signaling pathway GO:0007186 TAS
    chemokine-mediated signaling pathway GO:0070098 IBA
    negative regulation of cell proliferation GO:0008285 TAS
    cell cycle arrest GO:0007050 IDA
    cellular response to fibroblast growth factor stimulus GO:0044344 IEP
    cellular response to interleukin-1 GO:0071347 IEP
    chemotaxis GO:0006935 TAS
    neutrophil activation GO:0042119 TAS
    movement of cell or subcellular component GO:0006928 TAS
    cellular protein metabolic process GO:0044267 TAS
    embryonic digestive tract development GO:0048566 IEP
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    angiogenesis GO:0001525 TAS
    response to endoplasmic reticulum stress GO:0034976 IDA
    regulation of cell adhesion GO:0030155 IDA
    negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 IDA
    regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045091 IDA
    cellular response to lipopolysaccharide GO:0071222 IDA
    signal transduction GO:0007165 TAS
    induction of positive chemotaxis GO:0050930 IGI
    cellular response to tumor necrosis factor GO:0071356 IEP
    positive regulation of neutrophil chemotaxis GO:0090023 TAS
    neutrophil chemotaxis GO:0030593 IGI
Subcellular Localization
    intracellular GO:0005622 TAS
    extracellular space GO:0005615 IEA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified CXCL8 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CXCL8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL5  
Reconstituted Complex Homo sapiens
2 IL8RB  
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
3 SDC1 6382
Reconstituted Complex Homo sapiens
4 GNAI2 2771
Invivo Homo sapiens
5 CXCL8 3576
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
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