Gene description for FNBP1L
Gene name formin binding protein 1-like
Gene symbol FNBP1L
Other names/aliases C1orf39
TOCA1
Species Homo sapiens
 Database cross references - FNBP1L
ExoCarta ExoCarta_54874
Vesiclepedia VP_54874
Entrez Gene 54874
HGNC 20851
MIM 608848
UniProt Q5T0N5  
 FNBP1L identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FNBP1L
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    cadherin binding GO:0045296 HDA
    GTPase binding GO:0051020 IPI
Biological Process
    vesicle budding from membrane GO:0006900 IDA
    autophagy GO:0006914 IEA
    signal transduction GO:0007165 IEA
    membrane invagination GO:0010324 IDA
    vesicle organization GO:0016050 IDA
    vesicle transport along actin filament GO:0030050 IDA
    positive regulation of filopodium assembly GO:0051491 IDA
    cilium assembly GO:0060271 IMP
    clathrin-dependent endocytosis GO:0072583 IDA
    plasma membrane tubulation GO:0097320 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    cell cortex GO:0005938 IEA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified FNBP1L in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FNBP1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SBDS 51119
Affinity Capture-MS Homo sapiens
2 SNX27 81609
Affinity Capture-MS Homo sapiens
3 ACP1 52
Two-hybrid Homo sapiens
4 SNX24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SGSM2  
Two-hybrid Homo sapiens
6 RBPJ 3516
Affinity Capture-MS Homo sapiens
7 USP13  
Two-hybrid Homo sapiens
8 RIN3  
Affinity Capture-MS Homo sapiens
9 Nup188  
Affinity Capture-MS Mus musculus
10 Rbm8a  
Affinity Capture-MS Mus musculus
11 WASF1 8936
Co-fractionation Homo sapiens
12 PACSIN3 29763
Co-fractionation Homo sapiens
13 SHMT2 6472
Affinity Capture-RNA Homo sapiens
14 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
15 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
16 HNRNPK 3190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NXF1 10482
Affinity Capture-RNA Homo sapiens
18 CDC42 998
Affinity Capture-Western Homo sapiens
19 SF3A1 10291
Co-fractionation Homo sapiens
20 CAPZB 832
Affinity Capture-MS Homo sapiens
21 ARHGAP44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CDH1 999
Proximity Label-MS Homo sapiens
23 EZH2  
Affinity Capture-MS Homo sapiens
24 Kif4  
Affinity Capture-MS Mus musculus
25 GIPC1 10755
Proximity Label-MS Homo sapiens
26 FOS 2353
Affinity Capture-MS Homo sapiens
27 NUBP1 4682
Affinity Capture-MS Homo sapiens
28 COA7  
Co-fractionation Homo sapiens
29 FNBP1 23048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CYFIP1 23191
Co-fractionation Homo sapiens
31 DCLRE1B  
Affinity Capture-MS Homo sapiens
32 DNM2 1785
Reconstituted Complex Homo sapiens
33 ATG3 64422
Affinity Capture-Western Homo sapiens
34 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
35 WASL 8976
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here