Gene description for UNC80
Gene name unc-80 homolog (C. elegans)
Gene symbol UNC80
Other names/aliases C2orf21
UNC-80
Species Homo sapiens
 Database cross references - UNC80
ExoCarta ExoCarta_285175
Vesiclepedia VP_285175
Entrez Gene 285175
HGNC 26582
MIM 612636
UniProt Q8N2C7  
 UNC80 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
 Gene ontology annotations for UNC80
Molecular Function
    monoatomic cation channel activity GO:0005261 IBA
Biological Process
    monoatomic cation homeostasis GO:0055080 IBA
    monoatomic cation transmembrane transport GO:0098655 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    axon GO:0030424 IBA
    cation channel complex GO:0034703 IBA
 Experiment description of studies that identified UNC80 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for UNC80
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COPS5 10987
Affinity Capture-MS Homo sapiens
2 AURKB 9212
Affinity Capture-MS Homo sapiens
3 ZNF687  
Co-fractionation Homo sapiens
4 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
5 EGFR 1956
Affinity Capture-MS Homo sapiens
6 ZNF827  
Co-fractionation Homo sapiens
7 KIF14 9928
Affinity Capture-MS Homo sapiens
8 TRIM33 51592
Affinity Capture-MS Homo sapiens
9 TIMMDC1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which UNC80 is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Stimuli-sensing channels TAS Reactome
Transport of small molecules TAS Reactome





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