Gene description for EXT2
Gene name exostosin glycosyltransferase 2
Gene symbol EXT2
Other names/aliases SOTV
Species Homo sapiens
 Database cross references - EXT2
ExoCarta ExoCarta_2132
Entrez Gene 2132
HGNC 3513
MIM 608210
UniProt Q93063  
 EXT2 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for EXT2
Molecular Function
    protein heterodimerization activity GO:0046982 IPI
    heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 NAS
    transferase activity, transferring glycosyl groups GO:0016757 IDA
    metal ion binding GO:0046872 IEA
    N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 NAS
    glucuronosyltransferase activity GO:0015020 IDA
    glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 IEA
    acetylglucosaminyltransferase activity GO:0008375 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    mesoderm formation GO:0001707 IEA
    ossification GO:0001503 IMP
    protein glycosylation GO:0006486 IEA
    glycosaminoglycan biosynthetic process GO:0006024 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    signal transduction GO:0007165 TAS
    small molecule metabolic process GO:0044281 TAS
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IMP
    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 IMP
    cell differentiation GO:0030154 IEA
    carbohydrate metabolic process GO:0005975 TAS
    cellular polysaccharide biosynthetic process GO:0033692 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    Golgi apparatus GO:0005794 ISS
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 IDA
    endoplasmic reticulum GO:0005783 ISS
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    UDP-N-acetylglucosamine transferase complex GO:0043541 IDA
 Experiment description of studies that identified EXT2 in exosomes
Experiment ID 66
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for EXT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNTF  
Affinity Capture-MS Homo sapiens
2 TRAP1 10131
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 FABP4  
Affinity Capture-MS Homo sapiens
4 RPS29 6235
Affinity Capture-MS Homo sapiens
5 HNF4A  
Affinity Capture-MS Homo sapiens
6 GALNT5 11227
Invitro Homo sapiens
Two-hybrid Homo sapiens
7 CLEC2L  
Affinity Capture-MS Homo sapiens
8 CRB1  
Affinity Capture-MS Homo sapiens
9 EXT1 2131
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 EXT2 2132
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
11 TCEB1 6921
Affinity Capture-MS Homo sapiens
12 STK16  
Affinity Capture-MS Homo sapiens
13 SNCG 6623
Affinity Capture-MS Homo sapiens
14 HYOU1 10525
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EXT2 is involved
Defective EXT2 causes exostoses 2 TAS Reactome
HS-GAG biosynthesis TAS Reactome

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