Gene description for Cblb
Gene name Casitas B-lineage lymphoma b
Gene symbol Cblb
Other names/aliases AI429560
AI851073
Cbl-b
Species Mus musculus
 Database cross references - Cblb
ExoCarta ExoCarta_208650
Entrez Gene 208650
UniProt Q3TTA7  
 Cblb identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cblb
Molecular Function
    protein-glycine ligase activity GO:0070735 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    protein kinase binding GO:0019901 ISO
    tubulin-glycine ligase activity GO:0070738 IEA
    ubiquitin-protein transferase activity GO:0004842 IEA
    signal transducer activity GO:0004871 IEA
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
    protein-glycine ligase activity, initiating GO:0070736 IEA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    phosphotyrosine binding GO:0001784 IEA
    zinc ion binding GO:0008270 IEA
    calcium ion binding GO:0005509 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    protein-glutamic acid ligase activity GO:0070739 IEA
    ligase activity GO:0016874 IEA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    protein-glycine ligase activity, elongating GO:0070737 IEA
Biological Process
    regulation of signaling GO:0023051 IEA
    negative regulation of T cell receptor signaling pathway GO:0050860 IMP
    negative regulation of alpha-beta T cell proliferation GO:0046642 IMP
    cell surface receptor signaling pathway GO:0007166 IEA
    intracellular signal transduction GO:0035556 IMP
    T cell activation GO:0042110 IMP
    positive regulation of protein catabolic process GO:0045732 IMP
    signal transduction GO:0007165 ISO
    positive regulation of T cell anergy GO:0002669 IMP
    immune response GO:0006955 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleoplasm GO:0005654 ISO
    intracellular GO:0005622 IMP
    membrane raft GO:0045121 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Cblb in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cblb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cblb is involved
No pathways found





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