Gene description for Egfr
Gene name	epidermal growth factor receptor
Gene symbol	Egfr
Other names/aliases	9030024J15Rik AI552599 Erbb Errb1 Errp Wa5 wa-2 wa2
Species	Mus musculus
Database cross references - Egfr
ExoCarta	ExoCarta_13649
Vesiclepedia	VP_13649
Entrez Gene	13649
UniProt	Q01279
Egfr identified in sEVs derived from the following tissue/cell type
Brain cancer cells	19109410
Breast cancer cells	34112803
Breast cancer cells	34112803
Mast cells	17486113

Gene ontology annotations for Egfr

Molecular Function     chromatin binding GO:0003682 ISO     chromatin binding GO:0003682 ISS     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 IMP     protein tyrosine kinase activity GO:0004713 ISO     protein tyrosine kinase activity GO:0004713 ISS     transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IGI     transmembrane receptor protein tyrosine kinase activity GO:0004714 IMP     transmembrane signaling receptor activity GO:0004888 ISO     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IDA     epidermal growth factor receptor activity GO:0005006 IGI     epidermal growth factor receptor activity GO:0005006 IMP     epidermal growth factor receptor activity GO:0005006 ISO     epidermal growth factor receptor activity GO:0005006 ISO     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     signaling receptor binding GO:0005102 ISO     integrin binding GO:0005178 IEA     integrin binding GO:0005178 ISO     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 IEA     calmodulin binding GO:0005516 ISO     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     kinase activity GO:0016301 IDA     enzyme binding GO:0019899 ISO     kinase binding GO:0019900 ISO     protein kinase binding GO:0019901 IEA     protein kinase binding GO:0019901 ISO     protein phosphatase binding GO:0019903 IEA     protein phosphatase binding GO:0019903 ISO     protein tyrosine kinase activator activity GO:0030296 IEA     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     protein-containing complex binding GO:0044877 ISO     epidermal growth factor binding GO:0048408 IBA     epidermal growth factor binding GO:0048408 IDA     epidermal growth factor binding GO:0048408 ISO     actin filament binding GO:0051015 IEA     actin filament binding GO:0051015 ISO     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     cell morphogenesis GO:0000902 IGI     embryonic placenta development GO:0001892 IMP     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of protein phosphorylation GO:0001934 ISS     hair follicle development GO:0001942 IGI     hair follicle development GO:0001942 IMP     chromatin remodeling GO:0006338 IEA     translation GO:0006412 IEA     translation GO:0006412 ISO     response to oxidative stress GO:0006979 IEA     signal transduction GO:0007165 IDA     signal transduction GO:0007165 ISO     cell surface receptor signaling pathway GO:0007166 ISO     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IDA     epidermal growth factor receptor signaling pathway GO:0007173 IDA     epidermal growth factor receptor signaling pathway GO:0007173 IGI     epidermal growth factor receptor signaling pathway GO:0007173 IGI     epidermal growth factor receptor signaling pathway GO:0007173 IMP     epidermal growth factor receptor signaling pathway GO:0007173 IMP     epidermal growth factor receptor signaling pathway GO:0007173 ISO     epidermal growth factor receptor signaling pathway GO:0007173 ISO     multicellular organism development GO:0007275 IBA     salivary gland morphogenesis GO:0007435 IMP     midgut development GO:0007494 IEA     learning or memory GO:0007611 IEA     learning or memory GO:0007611 ISO     circadian rhythm GO:0007623 IEA     cell population proliferation GO:0008283 IGI     positive regulation of cell population proliferation GO:0008284 IDA     positive regulation of cell population proliferation GO:0008284 IGI     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISO     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     epidermis development GO:0008544 IMP     diterpenoid metabolic process GO:0016101 IEA     peptidyl-tyrosine phosphorylation GO:0018108 ISO     cerebral cortex cell migration GO:0021795 IMP     neurogenesis GO:0022008 IBA     positive regulation of cell growth GO:0030307 ISO     positive regulation of cell growth GO:0030307 ISS     lung development GO:0030324 IEA     positive regulation of cell migration GO:0030335 IEA     positive regulation of cell migration GO:0030335 ISO     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     positive regulation of superoxide anion generation GO:0032930 IEA     positive regulation of superoxide anion generation GO:0032930 ISO     positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO     response to cobalamin GO:0033590 IEA     response to hydroxyisoflavone GO:0033594 IEA     cellular response to reactive oxygen species GO:0034614 ISO     intracellular signal transduction GO:0035556 IEA     intracellular signal transduction GO:0035556 ISO     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     peptidyl-tyrosine autophosphorylation GO:0038083 ISO     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     ERBB2-EGFR signaling pathway GO:0038134 IDA     ERBB2-EGFR signaling pathway GO:0038134 IMP     ERBB2-EGFR signaling pathway GO:0038134 ISO     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IDA     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IMP     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 ISO     regulation of cell population proliferation GO:0042127 IGI     negative regulation of protein catabolic process GO:0042177 IEA     negative regulation of protein catabolic process GO:0042177 ISO     vasodilation GO:0042311 IEA     vasodilation GO:0042311 ISO     positive regulation of phosphorylation GO:0042327 ISO     ovulation cycle GO:0042698 IEA     ovulation cycle GO:0042698 ISO     hydrogen peroxide metabolic process GO:0042743 IEA     negative regulation of apoptotic process GO:0043066 IBA     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of MAP kinase activity GO:0043406 ISO     positive regulation of MAPK cascade GO:0043410 ISO     tongue development GO:0043586 IEA     positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 ISO     positive regulation of DNA repair GO:0045739 IEA     positive regulation of DNA repair GO:0045739 ISO     positive regulation of DNA replication GO:0045740 IEA     positive regulation of DNA replication GO:0045740 ISO     positive regulation of bone resorption GO:0045780 IEA     positive regulation of bone resorption GO:0045780 ISO     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of vasoconstriction GO:0045907 IEA     positive regulation of vasoconstriction GO:0045907 ISO     negative regulation of mitotic cell cycle GO:0045930 IEA     negative regulation of mitotic cell cycle GO:0045930 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     regulation of JNK cascade GO:0046328 ISO     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 ISO     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     astrocyte activation GO:0048143 IEA     astrocyte activation GO:0048143 ISO     positive regulation of fibroblast proliferation GO:0048146 IMP     digestive tract morphogenesis GO:0048546 IMP     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     neuron projection morphogenesis GO:0048812 IEA     neuron projection morphogenesis GO:0048812 ISO     epithelial cell proliferation GO:0050673 IMP     positive regulation of epithelial cell proliferation GO:0050679 IBA     positive regulation of epithelial cell proliferation GO:0050679 IMP     positive regulation of epithelial cell proliferation GO:0050679 ISO     regulation of peptidyl-tyrosine phosphorylation GO:0050730 IMP     regulation of peptidyl-tyrosine phosphorylation GO:0050730 ISO     response to calcium ion GO:0051592 IEA     response to calcium ion GO:0051592 ISO     regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO     positive regulation of glial cell proliferation GO:0060252 IEA     positive regulation of glial cell proliferation GO:0060252 ISO     morphogenesis of an epithelial fold GO:0060571 IMP     eyelid development in camera-type eye GO:0061029 IGI     response to UV-A GO:0070141 IEA     response to UV-A GO:0070141 ISO     positive regulation of mucus secretion GO:0070257 IEA     positive regulation of mucus secretion GO:0070257 ISO     regulation of ERK1 and ERK2 cascade GO:0070372 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     cellular response to amino acid stimulus GO:0071230 IDA     cellular response to mechanical stimulus GO:0071260 IEA     cellular response to cadmium ion GO:0071276 ISO     cellular response to growth factor stimulus GO:0071363 IDA     cellular response to epidermal growth factor stimulus GO:0071364 IEA     cellular response to epidermal growth factor stimulus GO:0071364 ISO     cellular response to estradiol stimulus GO:0071392 ISO     cellular response to estradiol stimulus GO:0071392 ISS     cellular response to xenobiotic stimulus GO:0071466 IEA     cellular response to dexamethasone stimulus GO:0071549 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 ISO     liver regeneration GO:0097421 IEA     liver regeneration GO:0097421 ISO     cell-cell adhesion GO:0098609 IEA     cell-cell adhesion GO:0098609 ISO     positive regulation of protein kinase C activity GO:1900020 ISO     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 ISO     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO     positive regulation of prolactin secretion GO:1902722 IEA     positive regulation of prolactin secretion GO:1902722 ISO     positive regulation of miRNA transcription GO:1902895 IEA     positive regulation of miRNA transcription GO:1902895 ISO     positive regulation of protein localization to early endosome GO:1902966 ISS     positive regulation of protein localization to plasma membrane GO:1903078 IEA     positive regulation of protein localization to plasma membrane GO:1903078 ISO     negative regulation of cardiocyte differentiation GO:1905208 IEA     negative regulation of cardiocyte differentiation GO:1905208 ISO Subcellular Localization     Golgi membrane GO:0000139 IEA     intracellular anatomical structure GO:0005622 IDA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 ISO     endosome GO:0005768 ISO     endosome GO:0005768 ISO     endosome GO:0005768 ISS     endoplasmic reticulum membrane GO:0005789 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IGI     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     basal plasma membrane GO:0009925 IBA     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     endosome membrane GO:0010008 ISO     membrane GO:0016020 ISO     basolateral plasma membrane GO:0016323 IDA     basolateral plasma membrane GO:0016323 ISO     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     cell junction GO:0030054 ISO     endocytic vesicle GO:0030139 IDA     endocytic vesicle GO:0030139 ISO     early endosome membrane GO:0031901 IEA     early endosome membrane GO:0031901 ISO     nuclear membrane GO:0031965 IEA     ruffle membrane GO:0032587 IEA     ruffle membrane GO:0032587 ISO     protein-containing complex GO:0032991 ISO     receptor complex GO:0043235 IBA     receptor complex GO:0043235 ISO     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 ISO     synaptic membrane GO:0097060 IEA     multivesicular body, internal vesicle lumen GO:0097489 IEA     multivesicular body, internal vesicle lumen GO:0097489 ISO     intracellular vesicle GO:0097708 ISO     glutamatergic synapse GO:0098978 IEA