Gene description for CDKN3
Gene name cyclin-dependent kinase inhibitor 3
Gene symbol CDKN3
Other names/aliases CDI1
Species Homo sapiens
 Database cross references - CDKN3
ExoCarta ExoCarta_1033
Entrez Gene 1033
HGNC 1791
MIM 123832
UniProt Q16667  
 CDKN3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CDKN3
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IDA
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 TAS
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of cell proliferation GO:0008285 TAS
    G1/S transition of mitotic cell cycle GO:0000082 TAS
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
    cell cycle arrest GO:0007050 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified CDKN3 in exosomes
Experiment ID 236
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDKN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK1 983
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 MS4A3  
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 CDC25A  
Invitro Homo sapiens
4 CDK2 1017
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 CDK3 1018
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
7 CDKN3 1033
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CDKN3 is involved
No pathways found

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