Gene description for PROZ
Gene name protein Z, vitamin K-dependent plasma glycoprotein
Gene symbol PROZ
Other names/aliases PZ
Species Homo sapiens
 Database cross references - PROZ
ExoCarta ExoCarta_8858
Vesiclepedia VP_8858
Entrez Gene 8858
HGNC 9460
MIM 176895
UniProt P22891  
 PROZ identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Urine 19056867    
 Gene ontology annotations for PROZ
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    proteolysis GO:0006508 IEA
    blood coagulation GO:0007596 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi lumen GO:0005796 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PROZ in sEVs
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PROZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 N4BP2L2 10443
Affinity Capture-MS Homo sapiens
3 FOXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 IQSEC1 9922
Affinity Capture-MS Homo sapiens
6 ZNHIT6 54680
Affinity Capture-MS Homo sapiens
7 SIK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MELK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 OR52W1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ACOT9 23597
Affinity Capture-MS Homo sapiens
11 HIGD1A 25994
Affinity Capture-MS Homo sapiens
12 ARVCF 421
Affinity Capture-MS Homo sapiens
13 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FOXG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 RICTOR 253260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TYW3  
Affinity Capture-MS Homo sapiens
17 CDC6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 XRCC6BP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EGFL7 51162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SDF2L1 23753
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SIPA1L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SENP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 KANK2 25959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DNAJB9 4189
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ETV3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 IP6K3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TUBB3 10381
Affinity Capture-MS Homo sapiens
30 SEPN1 57190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GNL3L 54552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 INTS6 26512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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