Gene description for SERAC1
Gene name serine active site containing 1
Gene symbol SERAC1
Other names/aliases -
Species Homo sapiens
 Database cross references - SERAC1
ExoCarta ExoCarta_84947
Vesiclepedia VP_84947
Entrez Gene 84947
HGNC 21061
MIM 614725
UniProt Q96JX3  
 SERAC1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SERAC1
Biological Process
    phospholipid biosynthetic process GO:0008654 IEA
    extracellular matrix organization GO:0030198 IEA
    intracellular cholesterol transport GO:0032367 IMP
    phosphatidylglycerol acyl-chain remodeling GO:0036148 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    extracellular matrix GO:0031012 IEA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
 Experiment description of studies that identified SERAC1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SERAC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 SFXN1 94081
Proximity Label-MS Homo sapiens
4 RAMP2  
Affinity Capture-MS Homo sapiens
5 SLC18A1  
Affinity Capture-MS Homo sapiens
6 SDF4 51150
Affinity Capture-MS Homo sapiens
7 EGFR 1956
Affinity Capture-MS Homo sapiens
8 AIFM1 9131
Proximity Label-MS Homo sapiens
9 GPR45  
Affinity Capture-MS Homo sapiens
10 CBWD1 55871
Affinity Capture-MS Homo sapiens
11 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
12 FAM71F2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SERAC1 is involved
No pathways found





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