Gene description for HSDL1
Gene name hydroxysteroid dehydrogenase like 1
Gene symbol HSDL1
Other names/aliases SDR12C3
Species Homo sapiens
 Database cross references - HSDL1
ExoCarta ExoCarta_83693
Vesiclepedia VP_83693
Entrez Gene 83693
HGNC 16475
UniProt Q3SXM5  
 HSDL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HSDL1
Molecular Function
    protein binding GO:0005515 IPI
    steroid dehydrogenase activity GO:0016229 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
 Experiment description of studies that identified HSDL1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HSDL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 TM4SF5  
Affinity Capture-MS Homo sapiens
3 CLPP 8192
Proximity Label-MS Homo sapiens
4 NT5E 4907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MECP2 4204
Affinity Capture-MS Homo sapiens
6 TM4SF20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 VIPR2  
Affinity Capture-MS Homo sapiens
10 CYB5B 80777
Affinity Capture-MS Homo sapiens
11 MTCH1 23787
Proximity Label-MS Homo sapiens
12 PITPNB 23760
Affinity Capture-MS Homo sapiens
13 TSPAN15 23555
Affinity Capture-MS Homo sapiens
14 LDLRAD1  
Affinity Capture-MS Homo sapiens
15 IFT20 90410
Affinity Capture-MS Homo sapiens
16 CD63 967
Affinity Capture-MS Homo sapiens
17 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 IMPDH1 3614
Affinity Capture-MS Homo sapiens
19 HCST  
Affinity Capture-MS Homo sapiens
20 PITPNA 5306
Affinity Capture-MS Homo sapiens
21 C3AR1  
Affinity Capture-MS Homo sapiens
22 MTCH2 23788
Proximity Label-MS Homo sapiens
23 CRELD1 78987
Affinity Capture-MS Homo sapiens
24 MDFI  
Affinity Capture-MS Homo sapiens
25 HTR3D  
Affinity Capture-MS Homo sapiens
26 TYROBP  
Affinity Capture-MS Homo sapiens
27 GAL  
Affinity Capture-MS Homo sapiens
28 KDSR 2531
Affinity Capture-MS Homo sapiens
29 FAM63B 54629
Affinity Capture-MS Homo sapiens
30 PICK1  
Affinity Capture-MS Homo sapiens
31 RTN4 57142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 OCIAD1 54940
Proximity Label-MS Homo sapiens
33 HSPA5 3309
Cross-Linking-MS (XL-MS) Homo sapiens
34 TOMM22 56993
Affinity Capture-MS Homo sapiens
35 TSPAN2 10100
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MGRN1 23295
Affinity Capture-MS Homo sapiens
37 PPTC7 160760
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 AKAP1 8165
Proximity Label-MS Homo sapiens
39 TSPAN8 7103
Affinity Capture-MS Homo sapiens
40 EDA2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RPA3 6119
Proximity Label-MS Homo sapiens
42 NTRK1 4914
Affinity Capture-MS Homo sapiens
43 COQ9  
Affinity Capture-MS Homo sapiens
44 CMTM5  
Affinity Capture-MS Homo sapiens
45 GPR21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 LPAR2 9170
Affinity Capture-MS Homo sapiens
47 TRABD 80305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TGFA  
Affinity Capture-MS Homo sapiens
49 HBB 3043
Affinity Capture-MS Homo sapiens
50 KCNJ6  
Affinity Capture-MS Homo sapiens
51 RNF13 11342
Affinity Capture-MS Homo sapiens
52 SLC31A1 1317
Affinity Capture-MS Homo sapiens
53 TSPAN31 6302
Affinity Capture-MS Homo sapiens
54 SAYSD1  
Affinity Capture-MS Homo sapiens
55 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 C1orf95  
Affinity Capture-MS Homo sapiens
57 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 ASB14  
Affinity Capture-MS Homo sapiens
59 IGHM 3507
Affinity Capture-MS Homo sapiens
60 C9orf72  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HSDL1 is involved
No pathways found





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