Gene description for GDF5
Gene name	growth differentiation factor 5
Gene symbol	GDF5
Other names/aliases	BDA1C BMP-14 BMP14 CDMP1 LAP-4 LAP4 OS5 SYM1B SYNS2
Species	Homo sapiens
Database cross references - GDF5
ExoCarta	ExoCarta_8200
Vesiclepedia	VP_8200
Entrez Gene	8200
HGNC	4220
MIM	601146
UniProt	P43026
GDF5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for GDF5

Molecular Function     cytokine activity GO:0005125 IBA     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IEA     BMP binding GO:0036122 IPI     identical protein binding GO:0042802 IPI Biological Process     chondrocyte differentiation GO:0002062 IEA     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     cell-cell signaling GO:0007267 TAS     response to mechanical stimulus GO:0009612 IEA     embryonic limb morphogenesis GO:0030326 IEA     BMP signaling pathway GO:0030509 IDA     positive regulation of BMP signaling pathway GO:0030513 IDA     negative regulation of chondrocyte differentiation GO:0032331 IDA     positive regulation of chondrocyte differentiation GO:0032332 IDA     forelimb morphogenesis GO:0035136 IEA     hindlimb morphogenesis GO:0035137 IEA     regulation of multicellular organism growth GO:0040014 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     ossification involved in bone remodeling GO:0043932 IEA     positive regulation of neuron differentiation GO:0045666 IEA     negative regulation of epithelial cell proliferation GO:0050680 IDA     positive regulation of SMAD protein signal transduction GO:0060391 IDA     chondroblast differentiation GO:0060591 IDA     mesenchymal cell apoptotic process GO:0097152 IEA     negative regulation of mesenchymal cell apoptotic process GO:2001054 IEA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     plasma membrane GO:0005886 IEA