Gene description for RTN2
Gene name reticulon 2
Gene symbol RTN2
Other names/aliases NSP2
NSPL1
NSPLI
SPG12
Species Homo sapiens
 Database cross references - RTN2
ExoCarta ExoCarta_6253
Vesiclepedia VP_6253
Entrez Gene 6253
HGNC 10468
MIM 603183
UniProt O75298  
 RTN2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for RTN2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    brain development GO:0007420 IBA
    gene expression GO:0010467 IEA
    neuron differentiation GO:0030182 IBA
    regulation of D-glucose import GO:0046324 ISS
    intracellular protein transmembrane transport GO:0065002 ISS
    endoplasmic reticulum tubular network formation GO:0071787 IBA
    negative regulation of amyloid-beta formation GO:1902430 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 NAS
    intermediate filament GO:0005882 ISS
    cell surface GO:0009986 IEA
    postsynaptic density GO:0014069 IBA
    terminal cisterna GO:0014802 ISS
    Z disc GO:0030018 ISS
    T-tubule GO:0030315 ISS
    sarcoplasmic reticulum membrane GO:0033017 IEA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified RTN2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RTN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFT2D1 113402
Affinity Capture-MS Homo sapiens
2 IFNGR2  
Affinity Capture-MS Homo sapiens
3 MCRS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SGCA  
Affinity Capture-MS Homo sapiens
5 NAT8B  
Affinity Capture-MS Homo sapiens
6 C4orf32  
Affinity Capture-MS Homo sapiens
7 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PLP1 5354
Affinity Capture-MS Homo sapiens
9 ICAM2 3384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 VAPA 9218
Affinity Capture-MS Homo sapiens
11 RTN3 10313
Affinity Capture-MS Homo sapiens
12 TNKS 8658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 VTN 7448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 JPH1 56704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TMEM128  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ATP1B4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TSPAN15 23555
Affinity Capture-MS Homo sapiens
18 IFITM3 10410
Affinity Capture-MS Homo sapiens
19 ATP1B3 483
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TMEM159 57146
Affinity Capture-MS Homo sapiens
21 COPA 1314
Affinity Capture-MS Homo sapiens
22 TNFSF18 8995
Affinity Capture-MS Homo sapiens
23 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TMEM169  
Affinity Capture-MS Homo sapiens
25 APEX1 328
Affinity Capture-RNA Homo sapiens
26 SYPL2  
Affinity Capture-MS Homo sapiens
27 GP5 2814
Affinity Capture-MS Homo sapiens
28 FANCG 2189
Two-hybrid Homo sapiens
29 C11orf87  
Affinity Capture-MS Homo sapiens
30 CMTM5  
Affinity Capture-MS Homo sapiens
31 COPB2 9276
Affinity Capture-MS Homo sapiens
32 NR2F2  
Affinity Capture-MS Homo sapiens
33 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TMEM31  
Affinity Capture-MS Homo sapiens
35 CD63 967
Affinity Capture-MS Homo sapiens
36 RTN1 6252
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 RTN4 57142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 MALL  
Affinity Capture-MS Homo sapiens
40 SVOPL  
Affinity Capture-MS Homo sapiens
41 TSPAN10 83882
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RTN2 is involved
No pathways found





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