Gene description for SFT2D1
Gene name SFT2 domain containing 1
Gene symbol SFT2D1
Other names/aliases C6orf83
pRGR1
Species Homo sapiens
 Database cross references - SFT2D1
ExoCarta ExoCarta_113402
Vesiclepedia VP_113402
Entrez Gene 113402
HGNC 21102
UniProt Q8WV19  
 SFT2D1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SFT2D1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    endomembrane system GO:0012505 IEA
    membrane GO:0016020 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
 Experiment description of studies that identified SFT2D1 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SFT2D1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC30A8  
Two-hybrid Homo sapiens
2 SCAND1  
Two-hybrid Homo sapiens
3 SDCBP 6386
Two-hybrid Homo sapiens
4 SYT16  
Two-hybrid Homo sapiens
5 TMEM255B  
Two-hybrid Homo sapiens
6 TMEM14B  
Two-hybrid Homo sapiens
7 VAMP3 9341
Affinity Capture-MS Homo sapiens
8 RTN2 6253
Affinity Capture-MS Homo sapiens
9 DIABLO 56616
Two-hybrid Homo sapiens
10 REEP4  
Two-hybrid Homo sapiens
11 HACD2 201562
Affinity Capture-MS Homo sapiens
12 STOM 2040
Two-hybrid Homo sapiens
13 TSPAN3 10099
Affinity Capture-MS Homo sapiens
14 ARFIP1 27236
Two-hybrid Homo sapiens
15 CDR2  
Affinity Capture-MS Homo sapiens
16 TMEM86B  
Two-hybrid Homo sapiens
17 PLEKHB2 55041
Two-hybrid Homo sapiens
18 TBRG4 9238
Two-hybrid Homo sapiens
19 DAGLB 221955
Affinity Capture-MS Homo sapiens
20 RABAC1 10567
Affinity Capture-MS Homo sapiens
21 MIEF2  
Two-hybrid Homo sapiens
22 FNDC3A 22862
Affinity Capture-MS Homo sapiens
23 SLC10A1  
Two-hybrid Homo sapiens
24 OTULIN 90268
Two-hybrid Homo sapiens
25 FAM134C 162427
Two-hybrid Homo sapiens
26 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
27 C12orf10 60314
Two-hybrid Homo sapiens
28 HERPUD1  
Affinity Capture-MS Homo sapiens
29 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
30 ATP11C 286410
Affinity Capture-MS Homo sapiens
31 SCN3B  
Two-hybrid Homo sapiens
32 KTN1 3895
Affinity Capture-MS Homo sapiens
33 CERCAM 51148
Two-hybrid Homo sapiens
34 TMX2 51075
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SFT2D1 is involved
No pathways found





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