Gene description for ADAM11
Gene name ADAM metallopeptidase domain 11
Gene symbol ADAM11
Other names/aliases MDC
Species Homo sapiens
 Database cross references - ADAM11
ExoCarta ExoCarta_4185
Entrez Gene 4185
HGNC 189
MIM 155120
UniProt O75078  
 ADAM11 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ADAM11
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    metallopeptidase activity GO:0008237 TAS
    integrin binding GO:0005178 TAS
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IEA
    integrin-mediated signaling pathway GO:0007229 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    extracellular matrix GO:0031012 ISS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified ADAM11 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ADAM11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STC2 8614
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ADAM11 is involved
No pathways found

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