Gene description for SLC16A10
Gene name solute carrier family 16 (aromatic amino acid transporter), member 10
Gene symbol SLC16A10
Other names/aliases MCT10
PRO0813
TAT1
Species Homo sapiens
 Database cross references - SLC16A10
ExoCarta ExoCarta_117247
Vesiclepedia VP_117247
Entrez Gene 117247
HGNC 17027
MIM 607550
UniProt Q8TF71  
 SLC16A10 identified in sEVs derived from the following tissue/cell type
Melanoma cells 25950383    
Melanoma cells 25950383    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC16A10
Molecular Function
    L-tyrosine transmembrane transporter activity GO:0005302 IDA
    protein binding GO:0005515 IPI
    amino acid transmembrane transporter activity GO:0015171 TAS
    aromatic amino acid transmembrane transporter activity GO:0015173 IDA
    L-phenylalanine transmembrane transporter activity GO:0015192 IDA
    L-tryptophan transmembrane transporter activity GO:0015196 IDA
    thyroid hormone transmembrane transporter activity GO:0015349 IDA
    transmembrane transporter activity GO:0022857 IBA
Biological Process
    amino acid transmembrane transport GO:0003333 IEA
    thyroid hormone generation GO:0006590 IEA
    amino acid transport GO:0006865 TAS
    monocarboxylic acid transport GO:0015718 IEA
    aromatic amino acid transport GO:0015801 IDA
    aromatic amino acid transport GO:0015801 TAS
    phenylalanine transport GO:0015823 IEA
    tryptophan transport GO:0015827 IEA
    tyrosine transport GO:0015828 IEA
    thyroid hormone transport GO:0070327 IBA
    thyroid hormone transport GO:0070327 IDA
    thyroid-stimulating hormone secretion GO:0070460 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 IDA
    basolateral plasma membrane GO:0016323 ISS
    basolateral plasma membrane GO:0016323 TAS
    cell junction GO:0030054 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified SLC16A10 in sEVs
1
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC16A10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK2 7379
Affinity Capture-MS Homo sapiens
2 TMEM14B  
Two-hybrid Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 KLK8 11202
Affinity Capture-MS Homo sapiens
5 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 EGLN3  
Affinity Capture-MS Homo sapiens
7 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 INSIG2  
Two-hybrid Homo sapiens
9 LRRC55  
Affinity Capture-MS Homo sapiens
10 LAMP1 3916
Proximity Label-MS Homo sapiens
11 GYG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CRELD1 78987
Affinity Capture-MS Homo sapiens
13 MGARP  
Affinity Capture-MS Homo sapiens
14 KEL  
Affinity Capture-MS Homo sapiens
15 FUNDC2 65991
Two-hybrid Homo sapiens
16 LRRC32 2615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 EDEM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LYZL6  
Affinity Capture-MS Homo sapiens
20 KLK1 3816
Affinity Capture-MS Homo sapiens
21 ARMC6 93436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ACTA1 58
Affinity Capture-MS Homo sapiens
23 SS18L2  
Affinity Capture-MS Homo sapiens
24 SLC3A2 6520
Affinity Capture-MS Homo sapiens
25 LAS1L 81887
Affinity Capture-MS Homo sapiens
26 LDLR 3949
Positive Genetic Homo sapiens
27 ERAP1 51752
Affinity Capture-MS Homo sapiens
28 UPK1A 11045
Affinity Capture-MS Homo sapiens
29 CNDP1  
Affinity Capture-MS Homo sapiens
30 REV3L  
Synthetic Growth Defect Homo sapiens
31 DHRS9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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