Gene description for CD209
Gene name CD209 molecule
Gene symbol CD209
Other names/aliases CDSIGN
CLEC4L
DC-SIGN
DC-SIGN1
Species Homo sapiens
 Database cross references - CD209
ExoCarta ExoCarta_30835
Vesiclepedia VP_30835
Entrez Gene 30835
HGNC 1641
MIM 604672
UniProt Q9NNX6  
 CD209 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD209
Molecular Function
    virus receptor activity GO:0001618 IDA
    protein binding GO:0005515 IPI
    D-mannose binding GO:0005537 IBA
    D-mannose binding GO:0005537 TAS
    carbohydrate binding GO:0030246 NAS
    pattern recognition receptor activity GO:0038187 IBA
    peptide antigen binding GO:0042605 NAS
    virion binding GO:0046790 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    adaptive immune response GO:0002250 IEA
    endocytosis GO:0006897 IEA
    immune response GO:0006955 IBA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 TAS
    leukocyte cell-cell adhesion GO:0007159 NAS
    cell-cell recognition GO:0009988 TAS
    virion attachment to host cell GO:0019062 TAS
    viral genome replication GO:0019079 NAS
    antigen processing and presentation GO:0019882 NAS
    intracellular signal transduction GO:0035556 NAS
    positive regulation of T cell proliferation GO:0042102 IDA
    regulation of T cell proliferation GO:0042129 IDA
    innate immune response GO:0045087 IEA
    symbiont entry into host cell GO:0046718 IDA
    peptide antigen transport GO:0046968 NAS
    intracellular transport of virus GO:0075733 TAS
    B cell adhesion GO:0097323 IDA
    positive regulation of viral life cycle GO:1903902 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 NAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 HDA
    membrane GO:0016020 TAS
    host cell GO:0043657 IEA
 Experiment description of studies that identified CD209 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD209
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL26  
Affinity Capture-MS Homo sapiens
2 HMGCR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CD209 30835
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
4 ZNF703  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 LSP1 4046
Affinity Capture-Western Homo sapiens
7 CEACAM5 1048
Affinity Capture-Western Homo sapiens
8 IKBKE 9641
Affinity Capture-Western Homo sapiens
9 NCK2 8440
Affinity Capture-MS Homo sapiens
10 FAM217B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CYLD  
Affinity Capture-Western Homo sapiens
12 CLU 1191
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 CLEC4M  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 HTR1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 VAC14 55697
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
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